The reemergence of pertussis in immunized populations: a case study.
OBJECTIVE: To present a case of classical pertussis occurring in previously vaccinated male siblings, 11 and 13 years of age, living in El Paso TX; also to present an overview and update of the changing epidemiology of pertussis including pathophysiology, diagnosis, and treatment. DESIGN: Nasopharyn...
| Publicado en: | Clinical Laboratory Science Vol. 18; no. 4; pp. 233 - 238 |
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| Autor principal: | |
| Formato: | case study Journal Article |
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American Society for Clinical Laboratory Science
Fall2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106391335&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106391335 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0894959X IKL jtl: Clinical Laboratory Science issn: 0894959X maglogo: N pubinfo: dt: Fall2005 vid: 18 iid: 4 pid: 13703 pub: American Society for Clinical Laboratory Science place: Dundee, Michigan artinfo: ui: 106391335 106391335 2009073016 NLM16315741 106391335 ppf: 233 ppct: 5 formats: fmt: @attributes: type: P tig: atl: The reemergence of pertussis in immunized populations: a case study. aug: au: Domínguez D affil: Associate Professor and Director, Clinical Laboratory Science Program, College of Health Sciences, University of Texas at El Paso, 1101 N Campbell, El Paso, TX 79902; delfina@utep.edu sug: subj: Whooping Cough Pertussis Vaccine Whooping Cough Epidemiology Whooping Cough Diagnosis Whooping Cough Physiopathology Child Adolescence Male Child: 6-12 years Adolescent: 13-18 years Male ab: OBJECTIVE: To present a case of classical pertussis occurring in previously vaccinated male siblings, 11 and 13 years of age, living in El Paso TX; also to present an overview and update of the changing epidemiology of pertussis including pathophysiology, diagnosis, and treatment. DESIGN: Nasopharyngeal swabs and blood samples were collected from two male siblings, 11 and 13 years of age, presenting with cold-like symptoms and persistent cough during the second week of infection. Nasopharyngeal swabs were plated onto Bordet-Gengou agar plates and incubated for 48 hours. Blood samples were analyzed for the presence of antibodies (IgM and IgA) against Bordetella pertussis antigens using indirect enzyme linked immunosorbent assay (ELISA). SETTING: Cultures and serological analysis was conducted at the University of Texas at El Paso, Clinical Laboratory Science Program Research facility. RESULTS: Bacterial cultures of both children were positive for Bordetella pertussis and the sera revealed positive IgM and IgA antibodies (> 11 PANBIO UNITS) against a mixture of antigens including: pertussis toxin, filamentous hemagglutinin, pertactin, and fimbriae. CONCLUSIONS: Pertussis immunity wanes overtime, leaving most adolescents and adults susceptible to infection. Physicians must be prepared to diagnose and treat pertussis in any age group regardless of vaccination status. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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