Clinical investigation on coexisting of duodenal ulcer and gastric cancer in China.

The aim of this study was to investigate the prevalence of coexistent duodenal ulcer and gastric cancer in China, then to explore the features of clinical manifestations, endoscopy, pathology and possible pathogenesis. A retrospective analysis has been made on medical records in Remin Hospital, Wuha...

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Publicado en:International Journal of Clinical Practice Vol. 59; no. 10; pp. 1153 - 1157
Autores principales: Zhao L, Shen Z, Luo H, Yu J
Formato: research tables/charts Journal Article
Publicado: Wiley-Blackwell Oct2005
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Oct2005
      vid: 59
      iid: 10
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        106391736
        106391736
        2009092499
        10.1111/j.1368-5031.2005.00594.x
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        106391736
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        atl: Clinical investigation on coexisting of duodenal ulcer and gastric cancer in China.
      aug:
        au:
          Zhao L
          Shen Z
          Luo H
          Yu J
        affil: Department of Gastroenterology, Remin Hospital of Wuhan University, Wuhan, China
      sug:
        subj:
          Comorbidity
          Peptic Ulcer Epidemiology
          Stomach Neoplasms Epidemiology
          Academic Medical Centers
          Aged
          China
          Female
          Gastroscopy
          Helicobacter Infections Prevention and Control
          Helicobacter Pylori
          Male
          Middle Age
          Neoplasm Staging
          Peptic Ulcer Diagnosis
          Peptic Ulcer Physiopathology
          Prevalence
          Record Review
          Retrospective Design
          Stomach Neoplasms Diagnosis
          Stomach Neoplasms Physiopathology
          Human
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
          Male
      ab: The aim of this study was to investigate the prevalence of coexistent duodenal ulcer and gastric cancer in China, then to explore the features of clinical manifestations, endoscopy, pathology and possible pathogenesis. A retrospective analysis has been made on medical records in Remin Hospital, Wuhan University, Hubei Province, China from January 1991 to December 2002. 37 cases of coexistent duodenal ulcer and gastric cancer were found. 24.3% (9/37) had previous history of duodenal ulcer. 81.0% (30/37) of them lack alarm symptoms or signs and 87.1% (27/31) had alleviation in abdominal pain by acid inhibitor. Duodenal ulcer was single in all cases with seven in A1 stage, three in A2 stage, one in H1 stage, one in H2 stage, seven in S1 stage and 18 in S2 stage. 89.2% (33/37) of concurrent gastric cancer were in the corpus and antrum, with 78.1% (29/37) of them belonging to Bormann type II and 87.1% (27/37) being moderately differentiated adenocarcinoma. 83.7% of patients (31/37) had positive rapid urease test. The coexisting gastric cancer in patients with duodenal ulcer is infrequent but not rare. Gastroscopy screening and routine follow-up are necessary for patients with duodenal ulcer. Helicobacter pylori may be important pathogen for it. Helicobacter pylori eradication is recommended in patients with duodenal ulcer to reduce the risk of contaminant gastric cancer.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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