Physiologic evidence for high-frequency chest wall oscillation and positive expiratory pressure breathing in hospitalized subjects with cystic fibrosis.

BACKGROUND AND PURPOSE: This investigation identified ventilation distribution, gas mixing, lung function, and arterial blood oxyhemoglobin saturation (SpO(2)) physiologic responses to 2 independent airway clearance treatments, high-frequency chest wall oscillation (HFCWO) and low positive expirator...

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Publicado en:Physical Therapy Vol. 85; no. 12; pp. 1278 - 1290
Autores principales: Darbee JC, Kanga JF, Ohtake PJ
Formato: pictorial research tables/charts Journal Article
Publicado: Oxford University Press / USA Dec2006
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2006
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      pub: Oxford University Press / USA
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        10.1093/ptj/85.12.1278
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        atl: Physiologic evidence for high-frequency chest wall oscillation and positive expiratory pressure breathing in hospitalized subjects with cystic fibrosis.
      aug:
        au:
          Darbee JC
          Kanga JF
          Ohtake PJ
        affil: Assistant Professor, Dept of Rehabilitation Sciences, Division of Physical Therapy, College of Health Sciences, University of Kentucky, 900 S Limestone St, Lexington, KY 40536; darbee@uky.edu
      sug:
        subj:
          Chest Physical Therapy Methods
          Cystic Fibrosis Therapy
          Ventilation, High Frequency
          Positive End-Expiratory Pressure
          Treatment Outcomes
          Oxygen Saturation
          Pulmonary Gas Exchange
          Respiratory Function Tests
          Mucus
          Comparative Studies
          Power Analysis
          Repeated Measures
          Analysis of Variance
          Data Analysis Software
          Post Hoc Analysis
          Adolescence
          Funding Source
          Human
          Adolescent: 13-18 years
      ab: BACKGROUND AND PURPOSE: This investigation identified ventilation distribution, gas mixing, lung function, and arterial blood oxyhemoglobin saturation (SpO(2)) physiologic responses to 2 independent airway clearance treatments, high-frequency chest wall oscillation (HFCWO) and low positive expiratory pressure (PEP) breathing, for subjects who had cystic fibrosis (CF) and who were hospitalized during acute and subacute phases of a pulmonary exacerbation. SUBJECTS: Fifteen subjects with moderate to severe CF were included in this study. METHODS: Subjects performed single-breath inert gas tests and spirometry before and immediately after HFCWO and PEP breathing at admission and discharge. Arterial blood oxyhemoglobin saturation was monitored throughout each treatment. RESULTS: At admission and discharge, PEP breathing increased SpO(2) during treatment, whereas HFCWO decreased SpO(2) during treatment. Ventilation distribution, gas mixing, and lung function improved after HFCWO or PEP breathing. DISCUSSION AND CONCLUSION: High-frequency chest wall oscillation and PEP breathing are similarly efficacious in improving ventilation distribution, gas mixing, and pulmonary function in hospitalized people with CF. Because SpO(2) decreases during HFCWO, people who have moderate to severe CF and who use HFCWO should have SpO(2) monitored during an acute exacerbation.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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