A fatal reaction to phenytoin-toxic epidermal necrolysis (TEN)

Toxic epidermal necrolysis (TEN) is a rare disorder characterised by a blistering and peeling of the top layer of skin. Internationally, the average incidence of TEN is 0.5-1.4 cases per million population per year and mortality is estimated to be 25-70%. It is important for nursing and medical staf...

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Publicado en:Australasian Journal of Neuroscience Vol. 17; no. 1; pp. 11 - 17
Autor principal: Wright KM
Formato: case study Journal Article
Publicado: Paradigm Publishing Services Jun-Dec2005
Acceso en línea:Ver este registro en EBSCOhost
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        atl: A fatal reaction to phenytoin-toxic epidermal necrolysis (TEN)
      aug:
        au: Wright KM
        affil: Neurosurgical Clinical Nurse Consultant/Case Manager, Department of Neurosurgery, The Liverpool Health Service, NSW
      sug:
        subj:
          Epidermal Necrolysis, Toxic Chemically Induced
          Phenytoin Adverse Effects
          Adult
          Adverse Drug Event
          Epidermal Necrolysis, Toxic Complications
          Epidermal Necrolysis, Toxic Diagnosis
          Epidermal Necrolysis, Toxic Therapy
          Female
          Adult: 19-44 years
          Female
      ab: Toxic epidermal necrolysis (TEN) is a rare disorder characterised by a blistering and peeling of the top layer of skin. Internationally, the average incidence of TEN is 0.5-1.4 cases per million population per year and mortality is estimated to be 25-70%. It is important for nursing and medical staff to be aware of the signs and symptoms of TEN, as early intervention is essential. This rare condition is explored by outlining the case of a 36 year old woman admitted to hospital with a head injury who died due to the development of TEN caused by a reaction to phenytoin. The causes, clinical features, diagnosis, treatment and complications of TEN are discussed in relation to this case study, and important issues highlighted.
      pubtype: Academic Journal
      doctype:
        case study
        Journal Article
      ougenre: Article
    language: English
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