Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory.
Alzheimer's disease is the most common cause of dementia in older adults. Although the cognitive deficits and pathologic hallmarks of Alzheimer's disease have been well characterized, few functional imaging studies have examined the functional competency of specific brain regions and their relations...
| Publicado en: | Brain: A Journal of Neurology Vol. 128; no. 4; pp. 773 - 788 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Apr2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106443187&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106443187 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00068950 2RY jtl: Brain: A Journal of Neurology issn: 00068950 maglogo: N pubinfo: dt: Apr2005 vid: 128 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106443187 NLM15705615 2009166317 10.1093/brain/awh400 NLM15705615 106443187 ppf: 773 ppct: 15 formats: tig: atl: Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory. aug: au: Golby A Silverberg G Race E Gabrieli S O'Shea J Knierim K Stebbins G Gabrieli J Golby, Alexandra Silverberg, Gerald Race, Elizabeth Gabrieli, Susan O'Shea, James Knierim, Kyle Stebbins, Glenn Gabrieli, John affil: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA sug: subj: Alzheimer's Disease Physiopathology Magnetic Resonance Imaging Memory Aged Case Control Studies Clinical Assessment Tools Correlation Coefficient Data Analysis, Statistical Descriptive Statistics Female Health Status Indicators Male Massachusetts Neuropsychological Tests Psychological Tests Human Aged: 65+ years Female Male ab: Alzheimer's disease is the most common cause of dementia in older adults. Although the cognitive deficits and pathologic hallmarks of Alzheimer's disease have been well characterized, few functional imaging studies have examined the functional competency of specific brain regions and their relationship to specific behavioural memory deficits in Alzheimer's disease. We used functional MRI (fMRI) to examine seven early stage Alzheimer's disease patients and seven healthy age-matched neurologically normal control subjects during intentional encoding of scenes. Subjects viewed blocks of novel scenes, repeated scenes or baseline. Data were analysed using whole-brain statistical parametric mapping and region of interest approaches. The Alzheimer's disease group demonstrated impaired explicit recognition memory, but intact implicit memory (repetition priming), for the scenes. Alzheimer's disease patients demonstrated a graded deficit in activation for novel versus repeated scenes along the ventral visual stream, with most impaired activation changes in the mesial temporal lobe (MTL) and fusiform regions, most preserved activations in primary visual cortex and variably affected activations in secondary visual areas. Group-level correlations with behavioural measures of explicit memory were found in MTL, lingual and fusiform areas, whereas correlations with priming were found in lateral occipital, parietal and frontal areas. Together, these fMRI findings indicate a dissociation in Alzheimer's disease between impaired explicit memory encoding in MTL and fusiform regions and intact implicit encoding in earlier-stage occipital cortex. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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