Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)
Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsycholo...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 35; no. 6; pp. 831 - 839 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106445731&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106445731 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Dec2005 vid: 35 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 106445731 106445731 2009169513 10.1007/s10803-005-0028-3 NLM16283082 106445731 ppf: 831 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS) aug: au: Gornick MC Addington AM Sporn A Gogtay N Greenstein D Lenane M Gochman P Ordonez A Balkissoon R Vakkalanka R Weinberger DR Rapoport JL Straub RE affil: Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD sug: subj: Carrier Proteins Phenotype Psychotic Disorders Familial and Genetic Schizophrenia Familial and Genetic Social Adjustment Adolescence Age of Onset Alleles Child Data Analysis Software Data Analysis, Statistical Descriptive Statistics Intelligence Tests P-Value Prospective Studies Research Instruments Scales Human Adolescent: 13-18 years Child: 6-12 years ab: Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p=.01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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