Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer [corrected] [published erratum appears in J CLIN ONCOL 2005 Jan 1;23(1):248].
PurposeChildren surviving acute lymphoblastic leukemia (ALL) and malignant brain tumors (BTs) have a higher incidence of attention and learning problems in school than do their healthy peers. The present study tests the hypothesis that the psychostimulant methylphenidate (MPH) improves cognitive and...
| Publicado en: | Journal of Clinical Oncology Vol. 22; no. 23; pp. 4743 - 4752 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
American Society of Clinical Oncology
12/1/2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106492267&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106492267 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0732183X 20D jtl: Journal of Clinical Oncology issn: 0732183X maglogo: N pubinfo: dt: 12/1/2004 vid: 22 iid: 23 pid: 26892 pub: American Society of Clinical Oncology place: Alexandria, Virginia artinfo: ui: 106492267 106492267 2005113833 NLM15570081 106492267 ppf: 4743 ppct: 9 formats: tig: atl: Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer [corrected] [published erratum appears in J CLIN ONCOL 2005 Jan 1;23(1):248]. aug: au: Mulhern RK Khan RB Kaplan S Helton S Christensen R Bonner M Brown R Xiong X Wu S Gururangan S Reddick WE affil: Division of Behavioral Medicine, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105-2794; raymond.mulhern@stjude.org sug: subj: Cancer Survivors In Infancy and Childhood Methylphenidate Therapeutic Use Attention Deficit Hyperactivity Disorder Drug Therapy Cognition Disorders Drug Therapy Treatment Complications, Delayed Attention Deficit Hyperactivity Disorder Etiology Neuropsychological Tests Behavior Rating Scales Scales Checklists Child Behavior Checklist Cognition Disorders Etiology Leukemia, Lymphocytic, Acute Complications Leukemia, Lymphocytic, Acute Complications Brain Neoplasms Complications Attention Deficit Hyperactivity Disorder Physiopathology Cognition Disorders Physiopathology Brain Neoplasms Therapy Brain Neoplasms Therapy Clinical Trials Crossover Design Data Analysis Software Repeated Measures Analysis of Variance Child Adolescence Female Male Funding Source Human Child: 6-12 years Adolescent: 13-18 years Female Male ab: PurposeChildren surviving acute lymphoblastic leukemia (ALL) and malignant brain tumors (BTs) have a higher incidence of attention and learning problems in school than do their healthy peers. The present study tests the hypothesis that the psychostimulant methylphenidate (MPH) improves cognitive and social functioning among these patients.Patients and MethodsWe report on 83 long-term survivors of ALL and BT identified as having attentional deficits on behavioral testing and parent or teacher report, and problems with academic achievement. The 47 male and 36 female patients ranged from 0.6 to 14.3 years (median, 5.4 years) of age at diagnosis and 6.7 to 17.9 years (median, 11.9 years) of age at participation. The patients (40 ALL, 43 BT) participated in a randomized, double-blind, 3-week home cross-over trial of placebo (bid), low-dose MPH (0.3 mg/kg; maximum dose, 10 mg bid), and moderate-dose MPH (0.6 mg/kg; maximum dose, 20 mg bid). The primary end points were weekly teacher and parent reports on the Conners' Rating Scales and Social Skills Rating System.ResultsCompared to placebo, significant improvement with MPH was reported by teachers and parents on the Conners' Rating Scales and by teachers on the Social Skills Rating System. However, no consistent advantage of moderate dose over low dose was observed. Of those participating, 66 (79.5%) of the 83 patients continued on best clinical management.ConclusionTreatment with MPH can at least temporarily reduce some attentional and social deficits among survivors of childhood ALL and BT. Long-term follow-up will reveal those subsets of patients who are more likely to benefit from MPH. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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