Recurrence of Helicobacter pylori infection 1 year after successful treatment: prospective cohort study in the Republic of Yemen.
Objectives: To investigate the prevalence of Helicobacter pylori infection in dyspeptic patients in the Republic of Yemen and the recurrence rate 1 year after apparently successful eradication.Methods: A total of 275 patients with chronic dyspepsia seen in one clinic were enrolled. Gastric biopsies...
| Published in: | European Journal of Gastroenterology & Hepatology Vol. 16; no. 12; pp. 1309 - 1315 |
|---|---|
| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Lippincott Williams & Wilkins
Dec2004
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106505380&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106505380 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Dec2004 vid: 16 iid: 12 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106505380 106505380 NLM15618837 2005125151 10.1097/00042737-200412000-00012 NLM15618837 106505380 ppf: 1309 ppct: 6 formats: tig: atl: Recurrence of Helicobacter pylori infection 1 year after successful treatment: prospective cohort study in the Republic of Yemen. aug: au: Gunaid AA Hassan NAG Murrya-Lyon IM Gunaid, Abdallah A Hassan, Nageeb Agm Murray-Lyon, Iain M affil: Department of Medicine, Al-Thawra Teaching Hospital, Faculty of Medicine and Health Sciences, University of Sana'a, Sana'a, Republic of Yemen sug: subj: Helicobacter Infections Epidemiology Drug Therapy, Combination Prevalence Dyspepsia Complications Antibiotics Therapeutic Use Helicobacter Infections Drug Therapy Biopsy Breath Tests Recurrence Time Factors Yemen Prospective Studies Data Analysis Software Confidence Intervals Chi Square Test Human ab: Objectives: To investigate the prevalence of Helicobacter pylori infection in dyspeptic patients in the Republic of Yemen and the recurrence rate 1 year after apparently successful eradication.Methods: A total of 275 patients with chronic dyspepsia seen in one clinic were enrolled. Gastric biopsies were obtained at endoscopy and H. pylori infection was diagnosed using the rapid urease test. Patients with H. pylori infection were given either clarithromycin or metronidazole-based triple therapy. Six weeks later H. pylori status was assessed using the C-urea breath test (C-UBT). Those who were negative for H. pylori had a further C-UBT after 1 year to establish the recurrence rate.Results: The prevalence of H. pylori infection at entry to the study was 82.2% [95% confidence interval (CI) 78-87%]. The overall eradication rate 6 weeks after treatment was 49.1% (95% CI 42.6-55.6%) by intention-to-treat analysis, and 60% (95% CI 53-67%) by per-protocol analysis. Recurrence rate of H. pylori infection at 1 year was 34% (95% CI 14-45%) and the only predictor of recurrence was an excess delta C-UBT value less than 3.5 per million but equal to or greater than 2.5 per million at 6 weeks after treatment (odds ratio 2.28; 95% CI 1.17-4.44; P = 0.028).Conclusion: The prevalence of H. pylori infection in dyspeptic patients in Yemen is very high, the eradication rate with standard triple therapy was unsatisfactory probably because of widespread bacterial resistance due to unrestricted antibiotic use. The recurrence rate of infection at 1 year was high, as a result of recrudescence of incompletely eradicated organisms rather than reinfection. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|