Rheumatoid arthritis-associated inflammatory leg ulcers: a new treatment for recalcitrant wounds.

Patients with rheumatoid arthritis may develop leg ulcers of varied aetiologies, including venous disease, infection and inflammation (vasculitis or pyoderma gangrenosum). The leg ulcers in rheumatoid arthritis patients may involve several of these aetiological factors and are often difficult to hea...

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Publicado en:International Wound Journal Vol. 1; no. 1; pp. 81 - 85
Autores principales: Coelho S, Amarelo M, Ryan S, Reddy M, Sibbald RG
Formato: pictorial research tables/charts Journal Article
Publicado: Wiley-Blackwell Apr2004
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2004
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        106513476
        2009020488
        10.1111/j.1742-481x.2004.0002.x
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        atl: Rheumatoid arthritis-associated inflammatory leg ulcers: a new treatment for recalcitrant wounds.
      aug:
        au:
          Coelho S
          Amarelo M
          Ryan S
          Reddy M
          Sibbald RG
        affil: Dermatology Day Care and Wound Healing Clinic, Women's College Ambulatory Care Centre, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
      sug:
        subj:
          Arthritis, Rheumatoid Complications
          Bandages and Dressings
          Leg Ulcer Etiology
          Leg Ulcer Therapy
          Aged
          Aged, 80 and Over
          Cellulose
          Collagen
          Compression Therapy
          Female
          Leg Ulcer Complications
          Peptide Hydrolases Physiology
          Pyoderma Gangrenosum Etiology
          Pyoderma Gangrenosum Therapy
          Treatment Outcomes
          Wound Healing
          Wound Infection Etiology
          Human
          Aged: 65+ years
          Aged, 80 & over
          Female
      ab: Patients with rheumatoid arthritis may develop leg ulcers of varied aetiologies, including venous disease, infection and inflammation (vasculitis or pyoderma gangrenosum). The leg ulcers in rheumatoid arthritis patients may involve several of these aetiological factors and are often difficult to heal. Both the ulcers and the treatments are often painful, and these ulcers may be present for years. A new oxidised regenerated cellulose and collagen dressing has been developed for slow-to-heal wounds and may have a role in the management of superficial inflammation that may persist in many of these ulcers, although clinically it is difficult to distinguish this from critical colonisation or frank infection. Venous disease requires compression therapy. Deep compartment infection should be treated with systemic antimicrobials, and inflammatory processes extending beyond the superficial wound base require disease-specific systemic anti-inflammatory agents. Four patients with recalcitrant wounds resistant to best practice were treated successfully with this new dressing combined with a strategy to control bacterial burden.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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