Dietary lignans: potential role in cancer prevention.
Recent in vitro, animal, and epidemiological studies suggest that dietary lignans may be chemopreventive, potentially through anti-estrogenic, anti-angiogenic, pro- apoptotic, and anti-oxidant mechanisms. In this article, we review lignan food sources and metabolism, proposed anti-carcinogenic mecha...
| Publicado en: | Nutrition & Cancer Vol. 51; no. 2; pp. 117 - 132 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106526716&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106526716 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2005 vid: 51 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106526716 106526716 2009036281 10.1207/s15327914nc5102_1 NLM15860433 106526716 ppf: 117 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Dietary lignans: potential role in cancer prevention. aug: au: Webb AL McCullough ML affil: Graduate Program in Nutrition and Health Sciences, Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322 sug: subj: Diet, Antineoplastic Neoplasms Prevention and Control Phytoestrogens Antioxidants Breast Neoplasms Epidemiology Cereals Colonic Neoplasms Epidemiology Female Fruit Male Neoplasms Risk Factors Phytoestrogens Pharmacodynamics Prostatic Neoplasms Epidemiology Vegetables Female Male ab: Recent in vitro, animal, and epidemiological studies suggest that dietary lignans may be chemopreventive, potentially through anti-estrogenic, anti-angiogenic, pro- apoptotic, and anti-oxidant mechanisms. In this article, we review lignan food sources and metabolism, proposed anti-carcinogenic mechanisms, and the evidence for a role of lignans in breast, colon, and prostate cancer prevention from animal and epidemiologic literature. Although a number of in vitro and animal studies support a role for lignan-rich foods and purified lignans in the modulation of cancer events of the breast, prostate, and colon, epidemiological studies, sparse and often retrospective in nature, offer inconsistent findings. The most support for a role of lignans in cancer is observed for premenopausal breast cancer. Additional epidemiological studies that use a prospective design and well-developed food databases and questionnaires are needed to adequately evaluate the role of lignans in cancer prevention. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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