Association of cytogenetic abnormalities with detection of BCR-ABL fusion transcripts in children with T-lineage lymphoproliferative diseases (T-ALL and T-NHL).
Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with b...
| Publicado en: | Pediatric Blood & Cancer Vol. 42; no. 3; pp. 278 - 281 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | case study pictorial Journal Article |
| Publicado: |
Wiley-Blackwell
2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106530111&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106530111 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15455009 1XL2 jtl: Pediatric Blood & Cancer issn: 15455009 maglogo: Y pubinfo: dt: 2004 vid: 42 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106530111 106530111 NLM14752867 2009040235 10.1002/pbc.10453 NLM14752867 106530111 ppf: 278 ppct: 3 formats: tig: atl: Association of cytogenetic abnormalities with detection of BCR-ABL fusion transcripts in children with T-lineage lymphoproliferative diseases (T-ALL and T-NHL). aug: au: Lo Nigro L Sainati L Mirabile E Lanciotti M Poli A Leszl A Basso G Lo Nigro, Luca Sainati, Laura Mirabile, Elena Lanciotti, Marina Poli, Amelia Leszl, Anna Basso, Giuseppe affil: Center of Pediatric Hematology and Oncology, University of Catania, Italy sug: subj: Chromosome Disorders Leukemia, Lymphocytic, Acute Familial and Genetic Lymphoma, T-Cell Familial and Genetic Adolescence Child Leukemia, Lymphocytic, Acute Diagnosis Leukemia, Lymphocytic, Acute Pathology Lymphoma, T-Cell Diagnosis Lymphoma, T-Cell Pathology Male Adolescent: 13-18 years Child: 6-12 years Male ab: Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript. pubtype: Academic Journal doctype: case study pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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