CD54 and CD62L expression by lymphoid cells in acute lymphoblastic leukemia in children...reprinted from British Journal of Biomedical Science 2003 60(3) with permission of the publisher
Altered expression or function of adhesion molecules on leukemic blasts may contribute to the evolution and biological behavior of acute leukemia. This work studies the expression of CD54 and CD62L by lymphoid cells and the serum level of the shed form of L-selectin (sL-selectin) in children with ac...
| Publicado en: | Journal of Continuing Education Topics & Issues Vol. 7; no. 3; pp. 136 - 143 |
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| Autores principales: | , , , |
| Formato: | CEU exam questions research tables/charts Journal Article |
| Publicado: |
American Medical Technologists
Aug2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106533982&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106533982 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15228606 IKA jtl: Journal of Continuing Education Topics & Issues issn: 15228606 maglogo: N pubinfo: dt: Aug2005 vid: 7 iid: 3 pid: 13698 pub: American Medical Technologists place: Rosemont, Illinois artinfo: ui: 106533982 106533982 2009031901 106533982 ppf: 136 ppct: 7 formats: fmt: @attributes: type: P tig: atl: CD54 and CD62L expression by lymphoid cells in acute lymphoblastic leukemia in children...reprinted from British Journal of Biomedical Science 2003 60(3) with permission of the publisher aug: au: Hafez FM Hassab H Morad Z Farag EAM affil: Departments of Pediatrics and Clinical Pathology, Faculty of Medicine, Alexandria University, Egypt sug: subj: Leukemia, Lymphocytic, Acute Blood Child Child, Preschool Descriptive Statistics Education, Continuing (Credit) Female Flow Cytometry Male P-Value Univariate Statistics Human Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Altered expression or function of adhesion molecules on leukemic blasts may contribute to the evolution and biological behavior of acute leukemia. This work studies the expression of CD54 and CD62L by lymphoid cells and the serum level of the shed form of L-selectin (sL-selectin) in children with acute lymphoblastic leukemia (ALL) at initial diagnosis and after first remission, and their relationship to disease activity and subtype. The study is conducted on 20 children (age range 2-10 years) newly diagnosed with ALL and admitted to Alexandria University Children's Hospital. Ten apparently healthy children of matched age and sex serve as a control group. Expression of CD54 and CD62L on mononuclear cells is detected by monoclonal antibodies using flow cytometry.Serum sL-selectin is measured by enzyme-linked immunosorbent assay (ELISA). B-cell ALL was the most common subtype (45%), followed by TALL (35%) and CALL (20%). CD54 and CD62L mean cellular expression, as well as serum sL-selectin level, were significantly higher at diagnosis than both after remission and in the control group. Univariate analysis showed that the presence of mediastinal mass, high leucocyte count, central nervous system involvement and low CD54 were significant predictors of mortality in children with ALL. pubtype: Academic Journal doctype: CEU exam questions research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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