Influenza.
Although most influenza infections are self-limited, few other diseases exert such a huge toll of suffering and economic loss. Despite the importance of influenza, there had been, until recently, little advance in its control since amantadine was licensed almost 40 years ago. During the past decade,...
| Publicado en: | Lancet Vol. 362; no. 9397; pp. 1733 - 1746 |
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| Autores principales: | , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Lancet
11/22/2003
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106578490&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106578490 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 11/22/2003 vid: 362 iid: 9397 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 106578490 106578490 NLM14643124 2005034140 10.1016/s0140-6736(03)14854-4 NLM14643124 106578490 ppf: 1733 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Influenza. aug: au: Nicholson KG Wood JM Zambon M Nicholson, Karl G Wood, John M Zambon, Maria affil: Infectious Diseases Unit, Leicester Royal Infirmary, Leicester, UK sug: subj: Influenza Antiviral Agents Therapeutic Use Disease Outbreaks Prevention and Control Hong Kong Influenza Vaccine Orthomyxoviridae Drug Effects Influenza Diagnosis Influenza Drug Therapy Influenza Epidemiology Influenza Microbiology Influenza Physiopathology World Health ab: Although most influenza infections are self-limited, few other diseases exert such a huge toll of suffering and economic loss. Despite the importance of influenza, there had been, until recently, little advance in its control since amantadine was licensed almost 40 years ago. During the past decade, evidence has accrued on the protection afforded by inactivated vaccines and the safety and efficacy in children of live influenza-virus vaccines. There have been many new developments in vaccine technology. Moreover, work on viral neuraminidase has led to the licensing of potent selective antiviral drugs, and economic decision modelling provides further justification for annual vaccination and a framework for the use of neuraminidase inhibitors. Progress has also been made on developing near-patient testing for influenza that may assist individual diagnosis or the recognition of widespread virus circulation, and so optimise clinical management. Despite these advances, the occurrence of avian H5N1, H9N2, and H7N7 influenza in human beings and the rapid global spread of severe acute respiratory syndrome are reminders of our vulnerability to an emerging pandemic. The contrast between recent cases of H5N1 infection, associated with high mortality, and the typically mild, self-limiting nature of human infections with avian H7N7 and H9N2 influenza shows the gaps in our understanding of molecular correlates of pathogenicity and underlines the need for continuing international research into pandemic influenza. Improvements in animal and human surveillance, new approaches to vaccination, and increasing use of vaccines and antiviral drugs to combat annual influenza outbreaks are essential to reduce the global toll of pandemic and interpandemic influenza. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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