Potential use of microarray technology for rapid identification of central nervous system pathogens.
Outbreaks of central nervous system (CNS) diseases result in significant productivity and financial losses, threatening peace and wartime readiness capabilities. To meet this threat, rapid clinical diagnostic tools for detecting and identifying CNS pathogens are needed. Current tools and techniques...
| Publicado en: | Military Medicine Vol. 169; no. 8; pp. 594 - 600 |
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| Autores principales: | , , , , , , , , , |
| Formato: | tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Aug2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106596585&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106596585 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: Aug2004 vid: 169 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106596585 106596585 NLM15379069 2005053180 10.7205/milmed.169.8.594 NLM15379069 106596585 ppf: 594 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Potential use of microarray technology for rapid identification of central nervous system pathogens. aug: au: Hanson EH Niemeyer DM Folio L Agan BK Rowley RK Hanson, Eric H Niemeyer, Debra M Folio, Les Agan, Brian K Rowley, Robb K affil: Office of the Air Force Surgeon General, Directorate of Modernization, Science, and Technology, 5201 Leesburg Pike, Suite 1401, Falls Church, VA, 22041, USA sug: subj: Disease Outbreaks Prevention and Control Meningitis, Meningococcal Cerebrospinal Fluid Meningitis, Meningococcal Epidemiology Neisseria Infections Cerebrospinal Fluid Adolescence Biological Warfare Classification Cost Benefit Analysis Male Military Medicine Public Health Adolescent: 13-18 years Male ab: Outbreaks of central nervous system (CNS) diseases result in significant productivity and financial losses, threatening peace and wartime readiness capabilities. To meet this threat, rapid clinical diagnostic tools for detecting and identifying CNS pathogens are needed. Current tools and techniques cannot efficiently deal with CNS pathogen diversity; they cannot provide real-time identification of pathogen serogroups and strains, and they require days, sometimes weeks, for examination of tissue culture. Rapid and precise CNS pathogen diagnostics are needed to provide the opportunity for tailored therapeutic regimens and focused preventive efforts to decrease morbidity and mortality. Such diagnostics are available through genetic and genomic technologies, which have the potential for reducing the time required in serogroup or strain identification from 500+ hours for some viral cultures to less than 3 hours for all pathogens. In the near future, microarray diagnostics and future derivations of these technologies will change the paradigm used for outbreak investigations and will improve health care for all. pubtype: Academic Journal doctype: tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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