Do risk factors for lactic acidosis influence dosing of metformin?
BACKGROUND: Metformin is commonly prescribed to treat type 2 diabetes mellitus, however it is associated with the potentially lethal condition of lactic acidosis. Prescribing guidelines have been developed to minimize the risk of lactic acidosis development, although some suggest they are inappropri...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 29; no. 5; pp. 449 - 455 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106598411&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106598411 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Oct2004 vid: 29 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106598411 2005055567 10.1111/j.1365-2710.2004.00589.x NLM15482389 106598411 ppf: 449 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Do risk factors for lactic acidosis influence dosing of metformin? aug: au: Millican S Cottrell N Green B affil: School of Pharmacy, University of Queensland, Brisbane sug: subj: Acidosis, Lactic Risk Factors Metformin Administration and Dosage Adult Aged Aged, 80 and Over Descriptive Statistics Diabetes Mellitus, Type 2 Drug Therapy Female Interviews Male Metformin Therapeutic Use Middle Age Prospective Studies Record Review Human Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: BACKGROUND: Metformin is commonly prescribed to treat type 2 diabetes mellitus, however it is associated with the potentially lethal condition of lactic acidosis. Prescribing guidelines have been developed to minimize the risk of lactic acidosis development, although some suggest they are inappropriate and have created confusion amongst prescribers. The aim of this study was to investigate whether metformin dose was influenced by the presence of risk factors for lactic acidosis. METHODS: The study was prospective, and retrieved information from patients admitted to hospital who were prescribed metformin at their time of admission. RESULTS: Eighty-three patients were included in the study, 60 of whom had a least one risk factor for lactic acidosis. Of those 60 patients, 78.3% had a dose adjustment, with renal impairment, hepatic impairment, surgery and use of radiological contrast media--the risk factors most likely to result in a dose adjustment. When dose adjustments did occur, metformin was withheld on 88.7% of occasions. CONCLUSION: Metformin dose was influenced by the presence of risk factors for lactic acidosis, although it was dependent upon the number and particular risk factor/s present. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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