Understanding and interpreting serum protein electrophoresis.
Serum protein electrophoresis is used to identify patients with multiple myeloma and other serum protein disorders. Electrophoresis separates proteins based on their physical properties, and the subsets of these proteins are used in interpreting the results. Plasma protein levels display reasonably...
| Publicado en: | American Family Physician Vol. 71; no. 1; pp. 105 - 117 |
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| Autores principales: | , , |
| Formato: | algorithm CEU exam questions pictorial tables/charts Journal Article |
| Publicado: |
American Academy of Family Physicians
1/1/2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106600516&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106600516 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0002838X AFP jtl: American Family Physician issn: 0002838X maglogo: N pubinfo: dt: 1/1/2005 vid: 71 iid: 1 pid: 1008 pub: American Academy of Family Physicians place: Skokie, Illinois artinfo: ui: 106600516 106600516 2005057654 NLM15663032 106600516 ppf: 105 ppct: 12 formats: tig: atl: Understanding and interpreting serum protein electrophoresis. aug: au: O'Connell TX Horita TJ Kasravi B affil: Kaiser Permanente Woodland Hills Family Medicine Residency Program, 5601 DeSoto Ave., Woodland Hills, CA 91365 sug: subj: Blood Protein Disorders Diagnosis Blood Protein Electrophoresis Blood Proteins Analysis Education, Continuing (Credit) Multiple Myeloma Diagnosis Paraproteinemias Diagnosis ab: Serum protein electrophoresis is used to identify patients with multiple myeloma and other serum protein disorders. Electrophoresis separates proteins based on their physical properties, and the subsets of these proteins are used in interpreting the results. Plasma protein levels display reasonably predictable changes in response to acute inflammation, malignancy, trauma, necrosis, infarction, burns, and chemical injury. A homogeneous spike-like peak in a focal region of the gamma-globulin zone indicates a monoclonal gammopathy. Monoclonal gammopathies are associated with a clonal process that is malignant or potentially malignant, including multiple myeloma, Waldenstrom's macroglobulinemia, solitary plasmacytoma, smoldering multiple myeloma, monoclonal gammopathy of undetermined significance, plasma cell leukemia, heavy chain disease, and amyloidosis. The quantity of M protein, the results of bone marrow biopsy, and other characteristics can help differentiate multiple myeloma from the other causes of monoclonal gammopathy. In contrast, polyclonal gammopathies may be caused by any reactive or inflammatory process. pubtype: Academic Journal doctype: algorithm CEU exam questions pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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