Strategies for detecting toxoplasma immunity...reprinted from the British Journal of Biomedical Science 2003 with permission of the publisher

A strategy for identifying toxoplasma immunity in pregnancy must provide good evidence of immunity but not falsely reassure; that for immunocompromised patients should' identify immunity and also the risk of reactivated toxoplasmosis. Using sera from both of these patient groups, the performance of...

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Publicado en:Journal of Continuing Education Topics & Issues Vol. 7; no. 1; pp. 38 - 43
Autores principales: Ashburn D, Evans R, Chatterton JMW, Joss AWL, Ho-Yen DO
Formato: CEU exam questions research tables/charts Journal Article
Publicado: American Medical Technologists Jan2005
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Strategies for detecting toxoplasma immunity...reprinted from the British Journal of Biomedical Science 2003 with permission of the publisher
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          Ashburn D
          Evans R
          Chatterton JMW
          Joss AWL
          Ho-Yen DO
        affil: Scottish Toxoplasma Reference Laboratory, Microbiology Department, Raigmore Hospital, Inverness, Scotland
      sug:
        subj:
          Toxoplasmosis Immunology
          Education, Continuing (Credit)
          False Positive Results
          Female
          Hematologic Tests
          Pregnancy
          Toxoplasmosis Diagnosis
          Human
          Female
      ab: A strategy for identifying toxoplasma immunity in pregnancy must provide good evidence of immunity but not falsely reassure; that for immunocompromised patients should' identify immunity and also the risk of reactivated toxoplasmosis. Using sera from both of these patient groups, the performance of an in-house IgG EIA and two commonly used commercial assays (Abbott AxSYM Toxo-G and Eiken latex test) were compared with the dye test. False-positive results were obtained using the IgG enzyme immunoassay (EIA) and AxSYM Toxo-G, and false negatives using all three screen tests. During pregnancy, positive results may falsely reassure, and patients should be tested for toxoplasma-specific IgM to differentiate between current infection and immunity. In immunocomprornised patients, positive results indicate immunity but negative results do not exclude it; these should be tested by dye test. Despite these reservations, we have demonstrated that immunity screening can be performed within a district general hospital.
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    language: English
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