N-acetyl-L-Cysteine as prophylaxis against sulfur mustard.
Sulfur mustard (HD) is a blister agent targeting the eyes, respiratory system, skin, and possibly other organs. Extensive exposure can destroy the immune system by destruction of bone marrow cells. There is no antidote for HD or effective treatment other than rapid decontamination. Clinical trials h...
| Publicado en: | Military Medicine Vol. 170; no. 1; pp. 52 - 57 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2005
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106612366&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106612366 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: Jan2005 vid: 170 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106612366 106612366 NLM15724855 2005074151 10.7205/milmed.170.1.52 NLM15724855 106612366 ppf: 52 ppct: 5 formats: fmt: @attributes: type: P tig: atl: N-acetyl-L-Cysteine as prophylaxis against sulfur mustard. aug: au: Bobb AJ Arfsten DP Jederberg WW Bobb, Andrew J Arfsten, Darryl P Jederberg, Warren W affil: Naval Health Research Center Detachment, Toxicology, 2729 R Street, Building 837, Area B, Wright Patterson AFB, OH 45433-7903, USA sug: subj: Acetylcysteine Therapeutic Use Chemical Warfare Agents Adverse Effects Mustard Compounds Adverse Effects Chemoprevention ab: Sulfur mustard (HD) is a blister agent targeting the eyes, respiratory system, skin, and possibly other organs. Extensive exposure can destroy the immune system by destruction of bone marrow cells. There is no antidote for HD or effective treatment other than rapid decontamination. Clinical trials have demonstrated activity for N-acetyl-L-cysteine (NAC) against a number of significant human pathologies involving free radicals, and animal and tissue studies have suggested efficacy for NAC as a chemoprotectant against many toxic chemicals. Among these are studies demonstrating that NAC significantly reduces the effects of HD and HD simulants, both in cultured cells and animals. Given the historical effectiveness of HD, the lack of any effective treatment, the demonstrated chemoprotective properties of NAC, its low toxicity, the lack of regulatory controls, and the data supporting efficacy against HD effects, we suggest daily oral administration of the maximum safe dose of NAC to personnel entering combat zones. pubtype: Academic Journal doctype: pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|