Computer-aided disease prediction system: development of application software with SAS component language.

Aims The intricacy of predictive models associated with prognosis and risk classification of disease often discourages medical personnel who are interested in this field. The aim of this study was therefore to develop a computer-aided disease prediction model underpinning a step-by-step statistics-g...

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Publicado en:Journal of Evaluation in Clinical Practice Vol. 11; no. 2; pp. 139 - 160
Autores principales: Chang C, Kuo H, Chang S, Chang H, Liou D, Laszlo T, Chen TH
Formato: clinical trial pictorial research tables/charts Journal Article
Publicado: Wiley-Blackwell Apr2005
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2005
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        106621661
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        10.1111/j.1365-2753.2005.00514.x
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        atl: Computer-aided disease prediction system: development of application software with SAS component language.
      aug:
        au:
          Chang C
          Kuo H
          Chang S
          Chang H
          Liou D
          Laszlo T
          Chen TH
        affil: Institute of Public Health, School of Medicine, National Yang-Ming University, Pei-Tou, Taipei, Taiwan
      sug:
        subj:
          Breast Neoplasms Prognosis
          Software
          Clinical Trials
          Consumer Satisfaction
          Cox Proportional Hazards Model
          Female
          Kaplan-Meier Estimator
          Logistic Regression
          Male
          Sweden
          Human
          Female
          Male
      ab: Aims The intricacy of predictive models associated with prognosis and risk classification of disease often discourages medical personnel who are interested in this field. The aim of this study was therefore to develop a computer-aided disease prediction model underpinning a step-by-step statistics-guided approach including five components: (1) data management; (2) exploratory analysis; (3) type of predictive model; (4) model verification; (5) interactive mode of disease prediction using SAS 8.02 Windows 2000 as a platform.Methods The application of this system was illustrated by using data from the Swedish Two-County Trial on breast cancer screening. The effects of tumour size, node status, and histological grade on breast cancer death using logistic regression model or survival models were predicted. A total of 20 questions were designed to exemplify the usefulness of each component. We also evaluated the system using a controlled randomized trial. Times to finish the above 20 questions were used as endpoint to evaluate the performance of the current system. User satisfaction with the current system such as easy to use, the efficiency of risk prediction, and the reduction of barrier to predictive model was also evaluated.Results The intervention group not only performed more efficiently than the control group but also satisfied with this application software.Conclusions The MD-DP-SOS system characterized by menu-driven style, comprehensiveness, accuracy and adequacy assessment, and interactive mode of disease prediction is helpful for medical personnel who are involved in disease prediction.
      pubtype: Academic Journal
      doctype:
        clinical trial
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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