Early experience alters brain function and structure.
OBJECTIVE: To investigate the effects of early experience on brain function and structure. METHODS: A randomized clinical trial tested the neurodevelopmental effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP). Thirty preterm infants, 28 to 33 weeks' gestat...
| Published in: | Pediatrics Vol. 113; no. 4; pp. 846 - 858 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | clinical trial diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Published: |
American Academy of Pediatrics
Apr2004
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106635661&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106635661 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00314005 PDT jtl: Pediatrics issn: 00314005 maglogo: N pubinfo: dt: Apr2004 vid: 113 iid: 4 pid: 1659 pub: American Academy of Pediatrics place: Elk Grove Village, Illinois artinfo: ui: 106635661 106635661 2005082810 10.1542/peds.113.4.846 NLM15060237 106635661 ppf: 846 ppct: 12 formats: tig: atl: Early experience alters brain function and structure. aug: au: Als H Duffy FH McAnulty GB Rivkin MJ Vajapeyam S Mulkern RV Warfield SK Huppi PS Butler SC Conneman N Fischer C Eichenwald EC affil: Harvard Medical School and Children's Hospital Boston, Enders Pediatric Research Laboratories, EN107, 320 Longwood Ave, Boston, MA 02115; heidelise.als@childrens.harvard.edu sug: subj: Brain In Infancy and Childhood Child Development Infant Behavior Infant Care Infant, Premature Behavior Rating Scales Brain Anatomy and Histology Brain Physiology Canonical Correlation Analysis Chi Square Test Data Analysis Software Electroencephalography Female Funding Source Infant Care Methods Infant, Newborn Intensive Care, Neonatal Learning Magnetic Resonance Imaging Male Massachusetts Multivariate Analysis of Variance Neuropsychological Tests Random Assignment Single-Blind Studies Univariate Statistics Human Infant, Newborn: birth-1 month Female Male ab: OBJECTIVE: To investigate the effects of early experience on brain function and structure. METHODS: A randomized clinical trial tested the neurodevelopmental effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP). Thirty preterm infants, 28 to 33 weeks' gestational age (GA) at birth and free of known developmental risk factors, participated in the trial. NIDCAP was initiated within 72 hours of intensive care unit admission and continued to the age of 2 weeks, corrected for prematurity. Control (14) and experimental (16) infants were assessed at 2 weeks' and 9 months' corrected age on health status, growth, and neurobehavior, and at 2 weeks' corrected age additionally on electroencephalogram spectral coherence, magnetic resonance diffusion tensor imaging, and measurements of transverse relaxation time. RESULTS: The groups were medically and demographically comparable before as well as after the treatment. However, the experimental group showed significantly better neurobehavioral functioning, increased coherence between frontal and a broad spectrum of mainly occipital brain regions, and higher relative anisotropy in left internal capsule, with a trend for right internal capsule and frontal white matter. Transverse relaxation time showed no difference. Behavioral function was improved also at 9 months' corrected age. The relationship among the 3 neurodevelopmental domains was significant. The results indicated consistently better function and more mature fiber structure for experimental infants compared with their controls. CONCLUSIONS: This is the first in vivo evidence of enhanced brain function and structure due to the NIDCAP. The study demonstrates that quality of experience before term may influence brain development significantly. pubtype: Academic Journal doctype: clinical trial diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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