Hormonal changes with cholesterol reduction: a double-blind pilot study.
BACKGROUND: The lowering of high serum cholesterol levels may be associated with increased non-cardiac mortality due to behavioral changes, although such endpoints are likely rare. OBJECTIVE: This current study sought to determine if hormonal changes accompany pharmacologically induced decreases in...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 29; no. 1; pp. 71 - 74 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106660154&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106660154 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Feb2004 vid: 29 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106660154 2004182485 10.1111/j.1365-2710.2003.00540.x NLM14748901 106660154 ppf: 71 ppct: 3 formats: fmt: @attributes: type: P tig: atl: Hormonal changes with cholesterol reduction: a double-blind pilot study. aug: au: Ormiston T Wolkowitz OM Reus VI Johnson R Manfredi F affil: Clinical Assistant Professor of Medicine, Stanford University School of Medicine, 751 S. Bascom Ave, San Jose, CA 95128-2699; thomas.ormiston@hhs.co.santa-clara.ca.us sug: subj: Cholesterol Drug Effects Hormones Drug Effects Statins Pharmacodynamics Adult Aged, 80 and Over Descriptive Statistics Female Male Paired T-Tests Pilot Studies Statins Adverse Effects Human Adult: 19-44 years Aged, 80 & over Female Male ab: BACKGROUND: The lowering of high serum cholesterol levels may be associated with increased non-cardiac mortality due to behavioral changes, although such endpoints are likely rare. OBJECTIVE: This current study sought to determine if hormonal changes accompany pharmacologically induced decreases in serum cholesterol levels. METHOD: Cholesterol, dopamine, homovanillic acid (HVA), serotonin, 5-HIAA, testosterone, cortisol and pregnenolone were measured at baseline and after 4 weeks of treatment. RESULTS: Subjects' cholesterol levels significantly declined within 4 weeks. Concomitant significant increase in dopamine and HVA were noted. CONCLUSION: Although this study is limited in size, it raises the possibility that cholesterol-lowering drug treatment is associated with hormonal perturbations. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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