Effects of modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment.
This study examined the effect of the psychostimulant modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment. Five men were randomly assigned to a modafinil (3 x 100 mg/24 hr) and a placebo trial on consecutive weeks, with a 5-day intervening 'wash-out' period. Ea...
| Publicado en: | Military Psychology Vol. 14; no. 1; pp. 23 - 48 |
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| Autores principales: | , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jan2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106689078&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106689078 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08995605 7MP jtl: Military Psychology issn: 08995605 maglogo: N pubinfo: dt: Jan2002 vid: 14 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106689078 106689078 2004014104 10.1207/s15327876mp1401_02 106689078 ppf: 23 ppct: 25 formats: fmt: @attributes: type: P tig: atl: Effects of modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment. aug: au: Baranski JV Gil V McLellan TM Moroz D Buguet A Radomski M affil: Defence and Civil Institute of Environmental Medicine, 1133 Sheppard Ave West, PO Box 2000, Toronto, Ontario, Canada M3M 3B9; joe.baranski@dciem.dnd.ca sug: subj: Cognition Nootropic Agents Therapeutic Use Sleep Deprivation Drug Therapy Adult Affect Analysis of Variance Canada Core Body Temperature Double-Blind Studies Fatigue Heat Humidity Motivation Neuropsychological Tests Placebos Post Hoc Analysis Questionnaires Random Assignment Repeated Measures Research, Military Self Assessment Students, Graduate Visual Analog Scaling Human Adult: 19-44 years ab: This study examined the effect of the psychostimulant modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment. Five men were randomly assigned to a modafinil (3 x 100 mg/24 hr) and a placebo trial on consecutive weeks, with a 5-day intervening 'wash-out' period. Each trial involved a thermoneutral control day (outside of the climatic chamber) followed by a 40-hr sleep deprivation period in a climatic chamber at 30° C with 50% relative humidity. Ten cognitive testing sessions were conducted on each trial; each session lasted approximately 45 min, and they occurred at 6-hr intervals. The task battery included subjective assessments of mood, fatigue, and motivation and cognitive assessments of serial reaction time, logical reasoning (logical reasoning task [LRT]), visual comparison (CMP), mental addition (ADD), vigilance (detection of repeated numbers [DRN]), and multitasking. In addition, for 4 of the cognitive tasks that permitted a quantitative index of response accuracy (i.e., LRT, CMP, DRN, and ADD), participants provided estimates of their performance before and after each session to permit an evaluation of the extent to which they could accurately self-monitor their own cognitive abilities. The findings revealed that (a) despite significant increases in core body temperature, cognitive performance was largely unaffected by the warm environment per se; (b) sleep loss induced a general reduction in cognitive performance that was largely but not completely eliminated by modafinil; and (c) participants were able to accurately self-monitor their own cognitive capabilities during both the placebo and modafinil trials. In this article, we discuss the potential utility of modafinil in sustained military operations and the general implications of these findings for Hancock's (1986) theory of sustained attention under thermal stress. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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