Arthroscopically guided Jamshidi needle biopsy of articular cartilage: potential utility in the evaluation of disease modifying osteoarthritis drugs (DMOADS)
Purpose: Studies of disease-modifying osteoarthritis drug (DMOAD) safety and effectiveness have relied on surrogate markers of disease activity (medical history, physical examination, radiographs, and magnetic resonance imaging). These often have low interobserver reliability and provide no informat...
| Publicado en: | Journal of Applied Research Vol. 3; no. 3; pp. 329 - 339 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Therapeutic Solutions LLC
Summer2003
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106709303&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106709303 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1537064X I4L jtl: Journal of Applied Research issn: 1537064X maglogo: N pubinfo: dt: Summer2003 vid: 3 iid: 3 pid: 13467 pub: Therapeutic Solutions LLC place: Newtown, Pennsylvania artinfo: ui: 106709303 106709303 2004041483 106709303 ppf: 329 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Arthroscopically guided Jamshidi needle biopsy of articular cartilage: potential utility in the evaluation of disease modifying osteoarthritis drugs (DMOADS) aug: au: Wei N Johnson LL Seely BL Delauter SK affil: Clinical Research Division, The Arthritis and Osteoporosis Center of Maryland, Frederick, Maryland sug: subj: Antirheumatic Agents Therapeutic Use Arthroscopy Methods Biopsy, Needle Methods Drug Evaluation Osteoarthritis Pathology Adult Aged Aged, 80 and Over Cartilage Pathology Injections, Intraarticular Middle Age Osteoarthritis Diagnosis Osteoarthritis Drug Therapy Retrospective Design Secondary Analysis Human Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years ab: Purpose: Studies of disease-modifying osteoarthritis drug (DMOAD) safety and effectiveness have relied on surrogate markers of disease activity (medical history, physical examination, radiographs, and magnetic resonance imaging). These often have low interobserver reliability and provide no information about cartilage quality. Assessment of cartilage histomorphology is a potentially valuable method for evaluating the extent of osteoarthritis (OA) and the effect of DMOADS on OA. Data on 126 arthroscopically guided small diameter (2 mm) Jamshidi needle cartilage biopsies from 32 patients (63 procedures with 2 biopsies obtained at each procedure) are reported.Type of Study: Retrospective analysis and description of technique.Methods: One hundred and twenty-six arthroscopically guided Jamshidi needle biopsies of articular cartilage were performed in 32 volunteers (10 men, 22 women; age range, 43-81 years) with Kellgren-Lawrence radiographic stage 1-3 OA of the knee in a randomized double-blinded placebo controlled study of insulin-like growth factor (IGF-1). Biopsies were obtained before treatment and also after 13 weeks of intra- articular injections. Patients were randomized to one of the 3 treatment groups: IGF given weekly or biweekly or placebo. Biopsies were obtained from the weight-bearing portion of the medial femoral condyle using a 2-mm Jamshidi needle and consisted of 2-mm diameter plugs of cartilage and underlying subchondral bone.Results: Adequate material for interpretation was obtained from the biopsies. The data obtained from the biopsies were comparable to the information obtained from larger conventional sections harvested in a companion study (wedge biopsies using a scalpel) before and after total knee arthroplasty. Ten cases of postprocedure hemarthrosis, all of which resolved spontaneously, were the only complications noted. The cases of hemarthrosis were seen only in the first 10 cases before strict complete non-weight-bearing restrictions were applied. Pain and WOMAC measurements worsened in fewer than 50% of patients during the 13 week course of the study. No other adverse clinical sequelae related to the study knee have been noted at between 24 to 48 months of follow-up.Conclusions: Arthroscopically-guided Jamshidi needle biopsy of articular cartilage from the weight-bearing surface of the medial femoral condyle may have potential utility for assessing the efficacy of DMOADs. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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