Longitudinal study on the prevalence of benzodiazepine (mis)use in a prison: importance of the analytical strategy.
AIMS: This study evaluates the suitability of gas chromatographic-mass spectrometric (GC-MS) analysis to follow-up the extent of benzodiazepine (mis)use in a Belgian prison population and compares it to other analytical strategies (e.g. screening followed by confirmation of the positive samples). DE...
| Publicado en: | Addiction Vol. 98; no. 10; pp. 1427 - 1433 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2003
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106710364&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106710364 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Oct2003 vid: 98 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106710364 106710364 2004042559 10.1046/j.1360-0443.2003.00527.x NLM14519180 106710364 ppf: 1427 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Longitudinal study on the prevalence of benzodiazepine (mis)use in a prison: importance of the analytical strategy. aug: au: Borrey D Meyer E Duchateau L Lambert W Van Peteghem C De Leenheer AP sug: subj: Antianxiety Agents, Benzodiazepine Prisoners Substance Abuse Detection Methods Antianxiety Agents, Benzodiazepine Urine Belgium Chromatography, Gas Comparative Studies Immunoassay Male McNemar's Test Prospective Studies Mass Spectrometry Human Male ab: AIMS: This study evaluates the suitability of gas chromatographic-mass spectrometric (GC-MS) analysis to follow-up the extent of benzodiazepine (mis)use in a Belgian prison population and compares it to other analytical strategies (e.g. screening followed by confirmation of the positive samples). DESIGN AND PARTICIPANTS: From February to August 1998, 598 persons were jailed of which 188 (31.4% of the incoming detainees) volunteered to be screened. Urine samples (530 in total) were collected on the day of arrival and after 14, 30 and 90 days of imprisonment. MEASUREMENTS: All samples were screened by EMIT(R) for benzodiazepines and analysed subsequently by GC-MS. FINDINGS: EMIT(R) screening yielded 117 (22.1%) positive samples, a number which increased to 174 (32.8%) after GC-MS analysis. Of these 174 GC-MS positive samples, 119 (68.4%) contained one benzodiazepine while for the remaining samples multiple benzodiazepine (mis)use could be demonstrated. A significant increase in benzodiazepine (mis)use was indicated only from day 0 to day 14 based on the GC-MS results but not on the immunoassay results, even when the latter were complemented with GC-MS analysis of the positively screened samples. The GC-MS data also demonstrated that benzodiazepines are mainly (mis)used by subjects on benzodiazepine prescription as almost 50% of these subjects took additional non-prescribed benzodiazepines. During GC-MS analysis other drugs were co-extracted unintentionally and chromatographed and 23.9% of the volunteers were positive for illegal drugs on the day of arrival. CONCLUSION: Immunoassay results yield an underestimation of the problem of benzodiazepine (mis)use in prison due to the high false negative rate. GC-MS analysis of all samples therefore is the recommended strategy for this type of longitudinal study as it yields more correct and detailed information than the immunoassay results. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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