T3 prostate cancer: how reliable is clinical staging?

The treatment of locally advanced stage T3 prostate carcinoma remains controversial. The reliability of the clinical assessment of extracapsular extension by digital rectal examination (DRE) is therefore crucial. Results from series of patients with T3 prostate cancer treated by radical prostatectom...

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Publicado en:Seminars in Urologic Oncology Vol. 15; no. 4; pp. 202 - 207
Autores principales: Ravery V, Boccon-Gibod L
Formato: review Journal Article
Publicado: W B Saunders 1997 Nov
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1997 Nov
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      pub: W B Saunders
      place: Philadelphia, Pennsylvania
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        atl: T3 prostate cancer: how reliable is clinical staging?
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        au:
          Ravery V
          Boccon-Gibod L
        affil: Department of Urology, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France
      sug:
        subj:
          Digital Rectal Examination
          Neoplasm Staging Evaluation
          Neoplasm Staging Methods
          Prostatic Neoplasms Physiopathology
          Biopsy
          Clinical Trials
          Magnetic Resonance Imaging
          Prostate Analysis
          Prostate-Specific Antigen Diagnostic Use
          Prostatic Neoplasms Blood
          Tomography, Emission-Computed
          Ultrasonography
      ab: The treatment of locally advanced stage T3 prostate carcinoma remains controversial. The reliability of the clinical assessment of extracapsular extension by digital rectal examination (DRE) is therefore crucial. Results from series of patients with T3 prostate cancer treated by radical prostatectomy indicate that DRE has shown a wide range of accuracy from 44% to 82%. The assessment of capsule perforation on biopsy provides a 96% specificity rate and a positive predictive value of 60%. Furthermore, if the apparent clinical status of the seminal vesicle is incorrect, sampling errors on biopsy may be substantial. Biopsy therefore appears to provide a more accurate assessment of the capsule than of the seminal vesicle. Information regarding the correlation between T3 clinical staging and conventional/endorectal coil magnetic resonance imaging staging is still needed. Finally, the accuracy rate of DRE for T3 staging increases to more than 90% if the prostate-specific antigen level is greater than 15 ng/mL. Copyright © 1997 by W B. Saunders Company
      pubtype: Periodical
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        review
        Journal Article
      ougenre: Article
    language: English
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