Inflammation of the gastric cardia in children with symptoms of acid peptic disease.
Objectives: To assess the severity and causes of inflammation of the gastric cardia in children undergoing endoscopy for symptoms of acid peptic disease.Study Design: Patients undergoing upper gastrointestinal endoscopy for symptoms of acid peptic disease had biopsies from gastric cardia, gastric, a...
| Publicado en: | Journal of Pediatrics Vol. 143; no. 4; pp. 520 - 525 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
2003 Oct
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106731939&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106731939 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00223476 04M jtl: Journal of Pediatrics issn: 00223476 maglogo: N pubinfo: dt: 2003 Oct vid: 143 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 106731939 106731939 NLM14571233 2004072068 NLM14571233 106731939 ppf: 520 ppct: 5 formats: tig: atl: Inflammation of the gastric cardia in children with symptoms of acid peptic disease. aug: au: Borrelli O Hassall E D'Armiento F Bosco S Mancini V Di Nardo G Bueno de Mesquita M Cucchiara S Borrelli, Osvaldo Hassall, Eric D'Armiento, Francesco Bosco, Sandro Mancini, Valentina Di Nardo, Giovanni Bueno de Mesquita, Mirjam Cucchiara, Salvatore affil: Departments of Pediatrics and Pathology, University of Naples Federico II, Naples, Italy sug: subj: Inflammation Etiology Peptic Ulcer Complications Stomach Adolescence Canada Child Child, Preschool Convenience Sample Descriptive Research Descriptive Statistics Female Gastric Acidity Determination In Infancy and Childhood Gastritis Etiology Helicobacter Infections Male Monitoring, Physiologic In Infancy and Childhood Prospective Studies Human Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Objectives: To assess the severity and causes of inflammation of the gastric cardia in children undergoing endoscopy for symptoms of acid peptic disease.Study Design: Patients undergoing upper gastrointestinal endoscopy for symptoms of acid peptic disease had biopsies from gastric cardia, gastric, and esophageal sites, and 24-hour intraesophageal pH monitoring. Gastric cardia was defined at endoscopy as the anatomic zone from the squamocolumnar junction to 0.5 cm below it. Severity of gastric cardia inflammation was scored 0 to 9 according to densities of inflammatory cells and epithelial abnormalities in surface and pit epithelium. A score > or =2 was considered positive.Results: Forty-seven children (median age, 6.5 years; range, 3-15) had Helicobacter pylori infection, gastroesophageal reflux disease (GERD), or both. In 22 patients, H pylori was detected in cardiac biopsies by rapid urease test and histology; it was detected also in the corpus and antrum in only seven of the 22. No patient had H pylori in gastric corpus/antrum without having the organism at the cardia as well. In 12 H pylori-positive patients, GERD was also diagnosed. Twenty-five patients had GERD and no H. pylori infection. Severity score was 3.8+/-0.8 in the H pylori group and 2.08+/-0.9 in the GERD alone group (P<.001); however, there was no difference in reflux index (24-hour % of gastroesophageal reflux) between the two groups. In neither group was correlation found between reflux index and severity score (H pylori, r=0.22; GERD alone, r=0.31; NS) nor between cardia inflammation and esophagitis grade (H pylori, r=0.37; GERD alone, r=0.22; NS).Conclusions: In children with symptoms of acid peptic disease, inflammation of the gastric cardia does occur. It is more severe when the cardiac zone is infected with H pylori than in its absence. Of major practical significance is the finding that the gastric cardia is a highly sensitive site for the detection of H pylori infection. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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