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Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.

Citicoline (CDP-choline; cytidine 5'-diphosphocholine), a form of the essential nutrient choline, shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer's disease. Citicoline has also been investigated as a therapy in stroke pati...

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Published in:Alternative Medicine Review Vol. 9; no. 1; pp. 17 - 32
Main Authors: Conant R, Schauss AG
Format: review tables/charts Journal Article
Published: Alternative Medicine Review LLC Mar2004
Online Access:View this record in EBSCOhost
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      pub: Alternative Medicine Review LLC
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        atl: Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.
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          Conant R
          Schauss AG
        affil: Director, Life Sciences Division, American Institute for Biosocial and Medical Research, Inc (AIBMR), Puyallup, WA
      sug:
        subj:
          Stroke Drug Therapy
          Cognition Disorders Drug Therapy
          Neuroprotective Agents Therapeutic Use
          Neuroprotective Agents Pharmacokinetics
          Neurotransmitters Drug Effects
          Alzheimer's Disease Drug Therapy
      ab: Citicoline (CDP-choline; cytidine 5'-diphosphocholine), a form of the essential nutrient choline, shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer's disease. Citicoline has also been investigated as a therapy in stroke patients, although the results of trials to date are inconclusive. Produced endogenously, citicoline serves as a choline donor in the metabolic pathways for biosynthesis of acetylcholine and neuronal membrane phospholipids, chiefly phosphatidylcholine. The principal components of citicoline, choline and cytidine, are readily absorbed in the GI tract and easily cross the blood-brain barrier. Exogenous citicoline, as the sodium salt, has been researched in animal experiments and human clinical trials that provide evidence of its cholinergic and neuroprotective actions. As a dietary supplement, citicoline appears useful for improving both the structural integrity and functionality of the neuronal membrane that may assist in membrane repair. This review, while not intended to be exhaustive, highlights the published, peer-reviewed research on citicoline with brief discussions on toxicology and safety, mechanisms of action, and pharmacokinetics.
      pubtype: Academic Journal
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        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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