Genomic approaches to the genetics of alcoholism.
When studying complex diseases such as alcoholism that develop as a result of numerous genetic and environmental factors, researchers can use the sequence data that have become available both for the human and for animal genomes. For these analyses, investigators are being aided by efforts to identi...
| Publicado en: | Alcohol Research & Health Vol. 26; no. 3; pp. 181 - 193 |
|---|---|
| Autores principales: | , |
| Formato: | pictorial tables/charts website Journal Article |
| Publicado: |
National Institute on Alcohol Abuse & Alcoholism
2002
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106786453&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106786453 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15357414 73T jtl: Alcohol Research & Health issn: 15357414 maglogo: N pubinfo: dt: 2002 vid: 26 iid: 3 pid: 491 pub: National Institute on Alcohol Abuse & Alcoholism place: Rockville, Maryland artinfo: ui: 106786453 106786453 2003162364 NLM12875046 106786453 ppf: 181 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Genomic approaches to the genetics of alcoholism. aug: au: Ehringer MA Sikela JM affil: Research Associate, Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado sug: subj: Alcoholism Familial and Genetic Databases Utilization DNA Analysis Genome, Human Informatics Information Resources World Wide Web ab: When studying complex diseases such as alcoholism that develop as a result of numerous genetic and environmental factors, researchers can use the sequence data that have become available both for the human and for animal genomes. For these analyses, investigators are being aided by efforts to identify and characterize functionally relevant DNA sequences in the entire genomic DNA sequence -- a process called annotation. Various bioinformatics and annotation tools can help in this enterprise. These include four primary approaches: (1) precomputed, annotated public Web sites that provide a plethora of information; (2) in-house analyses from which users can choose the appropriate analyses for their purposes; (3) Web-based annotation systems that analyze a user's DNA sequence; and (4) private resources that provide access to annotated genomic sequences at cost. In addition to careful study of the DNA sequence for clues about function, expression studies of mRNA levels using gene chips provide information about the activity levels of thousands of genes that may vary in different tissues, different animals and people, or under different environmental conditions. pubtype: Academic Journal doctype: pictorial tables/charts website Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|