Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxicillin for 1 week.
Objective: To study the relationship between daily alcohol consumption and the result of eradication therapy for Helicobacter pylori using omeprazole, clarithromycin and amoxicillin for 1 week.Design: Clinical trial.Setting: Urban health centre, general medicine section.Participants: One hundred and...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 14; no. 3; pp. 291 - 297 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2002 Mar
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106817934&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106817934 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2002 Mar vid: 14 iid: 3 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106817934 106817934 NLM11953695 2003046518 10.1097/00042737-200203000-00014 NLM11953695 106817934 ppf: 291 ppct: 6 formats: tig: atl: Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxicillin for 1 week. aug: au: Baena JM López C Hidalgo A Rams F Jiménez S García M Hernández MR Baena, José M López, Cristina Hidalgo, Antonio Rams, Francesc Jiménez, Sebastián García, Manuel Hernández, Maria R affil: Urban Health Centre Dr Carles Ribas, Barcelona, Spain sug: subj: Alcohol Drinking Helicobacter Infections Drug Therapy Clarithromycin Therapeutic Use Omeprazole Therapeutic Use Amoxicillin Therapeutic Use Antibiotics, Combined Treatment Outcomes Peptic Ulcer Microbiology Clinical Trials Logistic Regression Confidence Intervals Odds Ratio Data Analysis Software Chi Square Test Adult Middle Age Aged Female Male Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objective: To study the relationship between daily alcohol consumption and the result of eradication therapy for Helicobacter pylori using omeprazole, clarithromycin and amoxicillin for 1 week.Design: Clinical trial.Setting: Urban health centre, general medicine section.Participants: One hundred and fifty-six patients with a diagnosis of peptic ulcus or chronic gastritis. Helicobacter pylori infection was confirmed by the urease test, the 14C-urea breath test, IgG serology or biopsy.Interventions: A combination of omeprazole, 20 mg twice daily, clarithromycin, 500 mg twice daily, and amoxicillin, 1000 mg twice daily was administered for 1 week. No other drugs were given. Four to 8 weeks later a 14C-urea breath test was carried out to confirm eradication.Main Outcome Measures: Logistic regression was used to assess the relationship between eradication and daily alcohol consumption (main covariable), age, sex, smoking, length of illness, pathology studied (ulcus or gastritis) and therapeutic compliance.Results: Eradication (intention to treat analysis) was successful in 118 patients (75.6%; 95% CI, 68.9-82.4). The only variable significantly associated with the result of the therapy was daily alcohol consumption, with a higher probability of failure in non-consumers (29.9%) than in consumers (12.2%), adjusted OR 3.24 (95% CI, 1.12-9.20; P = 0.03). Eradication was dose dependent: 70.1% in abstemious patients (n = 107), rising to 79.3% in users of 4-16 g of pure ethanol a day (n = 29) and to 100% in users of 18-60 g daily (n = 20) with a P value of 0.005 for the trend.Conclusions: Daily alcohol consumption appears to have an additive effect in this eradication therapy. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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