A practical guide to antimicrobial management of complicated urinary tract infection.

Complicated urinary tract infection occurs in the setting of a functionally or structurally abnormal genitourinary tract. Many different abnormalities may lead to a designation of complicated urinary tract infection, and these abnormalities will have different influences on the frequency of infectio...

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Publicado en:Drugs & Aging Vol. 18; no. 4; pp. 243 - 255
Autor principal: Nicolle LE
Formato: review tables/charts Journal Article
Publicado: Springer Nature 2001
Acceso en línea:Ver este registro en EBSCOhost
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        atl: A practical guide to antimicrobial management of complicated urinary tract infection.
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        au: Nicolle LE
        affil: Department of Internal Medicine, University of Manitoba, Health Sciences Centre, GC430-820 Sherbrook Street, Winnipeg, MB R3A 1R9, Canada; lnicolle@hsc.mb.ca
      sug:
        subj:
          Antibiotics Therapeutic Use
          Urinary Tract Infections Complications
          Urinary Tract Infections Drug Therapy
          Diabetes Mellitus Complications
          Renal Insufficiency Complications
          Mycoses Complications
          Treatment Outcomes
          Urinary Catheterization Adverse Effects
          Urinary Tract Infections Diagnosis
          Urinary Tract Infections Microbiology
          Urinary Tract Infections Physiopathology
      ab: Complicated urinary tract infection occurs in the setting of a functionally or structurally abnormal genitourinary tract. Many different abnormalities may lead to a designation of complicated urinary tract infection, and these abnormalities will have different influences on the frequency of infection and likelihood of relapse or reinfection. The microbiology of complicated urinary tract infection is characterised by a greater variety of organisms and increased likelihood of antimicrobial resistance compared with acute uncomplicated urinary tract infection. Appropriate management requires a urine specimen for culture prior to institution of antimicrobial therapy, and ensuring that the underlying abnormality is fully characterised to determine whether it can be corrected. A wide variety of antimicrobial agents are effective for treatment, and are usually given for 7 to 14 days. If the underlying abnormality can be corrected, subsequent infections may be prevented. However, if the underlying abnormality cannot be corrected a high recurrence rate of infection, approaching 50% by 4 to 6 weeks, is expected. Further study of complicated urinary tract infection is necessary, including determination of when asymptomatic bacteriuria warrants treatment, and exploration of nonantimicrobial approaches to management.
      pubtype: Academic Journal
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        tables/charts
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      ougenre: Article
    language: English
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