Tacrolimus in dermatologic disorders.
Objective: To review the data surrounding the use of tacrolimus for skin disorders.Data Sources: Articles were obtained through a MEDLINE search of English-language literature (1990-May 2000); references of the retrieved publications were further reviewed for relevant literature.Study Selection: Org...
| Publicado en: | Annals of Pharmacotherapy Vol. 35; no. 5; pp. 582 - 589 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2001 May
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106836475&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106836475 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10600280 44V jtl: Annals of Pharmacotherapy issn: 10600280 maglogo: Y pubinfo: dt: 2001 May vid: 35 iid: 5 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 106836475 106836475 NLM11346066 2003070163 NLM11346066 106836475 ppf: 582 ppct: 7 formats: tig: atl: Tacrolimus in dermatologic disorders. aug: au: Skaehill PA Skaehill, P A affil: Mercy Health Center, Southwestern Oklahoma State University, Oklahoma City 73120, USA sug: subj: Antibiotics, Macrolide Therapeutic Use Skin Diseases Drug Therapy Alopecia Drug Therapy Clinical Trials Dermatitis, Atopic Drug Therapy Psoriasis Drug Therapy Skin Diseases Etiology Treatment Outcomes ab: Objective: To review the data surrounding the use of tacrolimus for skin disorders.Data Sources: Articles were obtained through a MEDLINE search of English-language literature (1990-May 2000); references of the retrieved publications were further reviewed for relevant literature.Study Selection: Orginal studies in humans regarding the use of tacrolimus for skin disorders were included.Data Extraction: The major outcomes extracted from the literature involved patient response to therapy and adverse effects.Data Synthesis: Tacrolimus offers an additional therapeutic approach to the treatment of immunologically based skin disorders. led trials and case reports indicates topical tacrolimus is a safe and effective alternative treatment in patients with atopic dermatitis. Case reports document efficacy in recalcitrant pyoderma gangrenosum, mucosal lichen planus, and ichthyosis linearis trolled trials and case reports indicate oral tacrolimus is effective in recalcitrant plaque psoriasis. Case reports document efficacy in recalcitrant pyoderma gangrenosum and leukocytclastic vascultis. The clinical utility of oral tacrolimus in skin disorders is limited due to potentially severe adverse effects such as infections, hypertension, hyperglcemia hyperkalemia, nephrotoxicity neurotoxicity, and increased risk of neoplasia.Conclusions: Most of the available data indicate short-term (3 wk to 3 mo) topical tacrolimus is a safe and effective treatment alternative for inflammatory skin disorders. Further study is needed to evaluate long-term safety and efficacy and to determine the best dosage regimen. Although oral tacrolimus has demonstrated efficacy in inflammatory skin disorders, the potenial for serious adverse effects limits its utility to third-line therapy for patients who are resistant to, or intolerant of, conventional therapies. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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