Quantification of Helicobacter pylori resistance in functional and organic dyspepsia.
OBJECTIVE: To compare the efficacy of Helicobacter pylori eradication in patients with functional and organic dyspepsia. METHODS: The study included a cohort of 160 patients (115 with organic and 45 with functional dyspepsia) with dyspeptic symptoms and gastroscopically confirmed H. pylori infection...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 27; no. 5; pp. 353 - 356 |
|---|---|
| Autores principales: | , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2002
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106843827&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106843827 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Oct2002 vid: 27 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106843827 2003087098 10.1046/j.1365-2710.2002.00428.x NLM12383136 106843827 ppf: 353 ppct: 3 formats: fmt: @attributes: type: P tig: atl: Quantification of Helicobacter pylori resistance in functional and organic dyspepsia. aug: au: Rosandic M Pilas V Bevanda M Falisevac V Korac B affil: Division of Gastroenterology, Department of Internal Medicine, University Hospital Rebro, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia; rosandic@hazu.hr sug: subj: Drug Resistance, Microbial Evaluation Dyspepsia Physiopathology Helicobacter Pylori Drug Effects Adolescence Adult Aged Bosnia-Herzegovina Chi Square Test Clinical Trials Comparative Studies Drug Therapy, Combination Endoscopy Female Helicobacter Infections Diagnosis Helicobacter Infections Drug Therapy In Vitro Studies Male Middle Age Omeprazole Therapeutic Use Prospective Studies Random Assignment Time Factors Treatment Duration Human Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: OBJECTIVE: To compare the efficacy of Helicobacter pylori eradication in patients with functional and organic dyspepsia. METHODS: The study included a cohort of 160 patients (115 with organic and 45 with functional dyspepsia) with dyspeptic symptoms and gastroscopically confirmed H. pylori infection. Triple therapy with omeprazole 20 mg, amoxicillin 1000 mg and metronidazole 400 mg (OAM) was administered twice a day for a week. Minimal inhibition concentration (MIC) was estimated on cultures from 41 patients with positive H. pylori for determination of antimicrobial sensitivity and primary resistance to amoxicillin and metronidazole. RESULTS: Endoscopic examination at least 6 weeks after therapy showed that 116 (72.5%) patients had H. pylori eradicated, whereas 44 (27.5%) were not. From the latter patients, 10 (23%) had functional dyspepsia and from 116 eradicated patients 35 (30%) had functional dyspepsia. Difference in efficacy of OAM therapy between patients with organic and functional dyspepsia was not significant (P > 0.5). Percentages of non-eradicated patients with organic and functional dyspepsia were 29.6 and 22.2%, respectively (ratio 1.3 : 1). MIC from 41 samples showed 18 (44%) in vitro resistant strains. There was no resistance to amoxicillin. CONCLUSIONS: There is no significant difference in H. pylori resistance to the same antibiotic between patients having functional or organic dyspepsia. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|