Advances in the understanding of clinical manifestations and therapy of severe sepsis: an update for critical care nurses.
Severe sepsis is a major public health concern and a burden on the healthcare system. Despite improvements in efforts to control the source of infection and increased recognition by healthcare providers of patients with the disease, the mortality rate remains unacceptably high, from 30% to 50%. The...
| Publicado en: | American Journal of Critical Care Vol. 12; no. 2; pp. 120 - 136 |
|---|---|
| Autores principales: | , , |
| Formato: | CEU exam questions glossary tables/charts Journal Article |
| Publicado: |
American Association of Critical-Care Nurses
Mar2003
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106851266&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106851266 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10623264 44L jtl: American Journal of Critical Care issn: 10623264 maglogo: N pubinfo: dt: Mar2003 vid: 12 iid: 2 pid: 2559 pub: American Association of Critical-Care Nurses place: Alisa Veijo, California artinfo: ui: 106851266 2003096439 10.4037/ajcc2003.12.2.120 NLM12625170 106851266 ppf: 120 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Advances in the understanding of clinical manifestations and therapy of severe sepsis: an update for critical care nurses. aug: au: Ely EW Kleinpell RM Goyette RE affil: Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Tennessee Valley Veterans Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville, TN sug: subj: Fibrinolytic Agents Multiple Organ Dysfunction Syndrome Drug Therapy Sepsis Drug Therapy Sepsis Symptoms Blood Coagulation Disorders C-Reactive Protein Clinical Trials Critical Care Nursing Education, Continuing (Credit) Fibrinolytic Agents Pharmacodynamics Multiple Organ Dysfunction Syndrome Physiopathology Multiple Organ Dysfunction Syndrome Symptoms Nursing Assessment Patient Selection Sepsis Sepsis Complications Sepsis Mortality Sepsis Prevention and Control Sepsis Prognosis Systemic Inflammatory Response Syndrome ab: Severe sepsis is a major public health concern and a burden on the healthcare system. Despite improvements in efforts to control the source of infection and increased recognition by healthcare providers of patients with the disease, the mortality rate remains unacceptably high, from 30% to 50%. The systemic inflammatory response syndrome criteria are used as diagnostic indicators of sepsis when they occur in patients with known or suspected infection. The outcome of a patient with severe sepsis is often related to the occurrence of sepsis-induced multiple organ dysfunction syndrome. Multiple organ dysfunction syndrome appears to result from a cascade of organism-related factors, inflammatory mediators, endothelial injury, disturbed hemostasis, and microcirculatory abnormalities. In patients with severe sepsis, derangements of inflammation and coagulation are tightly linked. Although numerous clinical trials focused on interventions in one or the other of the inflammatory and coagulation systems failed to show reduced mortality due to sepsis, a member of a new class of drugs called 'cogins' was effective. In its active form, protein C has anti-inflammatory, antithrombotic, and profibrinolytic properties that can reduce organ injury associated with severe sepsis. A recombinant form of activated protein C, drotrecogin alfa (activated), significantly reduces 28-day mortality due to all causes in patients with severe sepsis and has an acceptable safety profile. This review provides an overview of severe sepsis, highlighting recent advances in treatment of the disease and the role of critical care nurses. pubtype: Academic Journal doctype: CEU exam questions glossary tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|