Pyoderma gangrenosum: case report of novel treatment with topical steroid and silver sulfadiazine.

Ulceration and chronic wounds as a result of pyoderma gangrenosum can be recalcitrant to standard treatment. The mainstay of treatment has traditionally been immunosuppressive therapy given orally and/or parenterally. The use of topical medications in wound care is not new. Obtaining bacterial balan...

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Publicado en:Wounds: A Compendium of Clinical Research & Practice Vol. 14; no. 6; pp. 227 - 230
Autores principales: Walusimbi M, Mannari RJ, Payne WG, Ochs D, Blue ML, Robson MC
Formato: case study pictorial Journal Article
Publicado: HMP Global 2002 Jul-Aug Supplement
Acceso en línea:Ver este registro en EBSCOhost
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      pub: HMP Global
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        atl: Pyoderma gangrenosum: case report of novel treatment with topical steroid and silver sulfadiazine.
      aug:
        au:
          Walusimbi M
          Mannari RJ
          Payne WG
          Ochs D
          Blue ML
          Robson MC
        affil: Institute for Tissue Regeneration, Repair, and Rehabilitation, Dept of Veterans Affairs Medical Center, Bay Pines, FL
      sug:
        subj:
          Methylprednisolone Administration and Dosage
          Pyoderma Gangrenosum Drug Therapy
          Silver Sulfadiazine Administration and Dosage
          Administration, Topical
          Aged
          Drug Combinations
          Leg Ulcer Drug Therapy
          Leg Ulcer Etiology
          Leg Ulcer Microbiology
          Male
          Wound Healing
          Aged: 65+ years
          Male
      ab: Ulceration and chronic wounds as a result of pyoderma gangrenosum can be recalcitrant to standard treatment. The mainstay of treatment has traditionally been immunosuppressive therapy given orally and/or parenterally. The use of topical medications in wound care is not new. Obtaining bacterial balance in order for progressive wound healing to proceed is a must. Topical delivery of antibiotics is superior to parenterally delivered antibiotics in treating wounds with granulation tissue. Although no reports of the ability of the body to deliver immunosuppressive medication to granulating wounds exist, topical therapy may indeed be more effective. The authors report a case of successful treatment of pyoderma gangrenosum with combination therapy including topical antimicrobial therapy and topical steroids (methylprednisolone).
      pubtype: Periodical
      doctype:
        case study
        pictorial
        Journal Article
      ougenre: Article
    language: English
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