Population pharmacokinetics of intravenous valproic acid in Korean patients.
OBJECTIVE: To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults. METHODS: Valproic acid concentrations were obtained using a peak and trough sampling scheme for 102 Korean epileptic patients who were no...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 27; no. 6; pp. 419 - 426 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2002
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106864814&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106864814 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Dec2002 vid: 27 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106864814 2003121531 10.1046/j.1365-2710.2002.00440.x NLM12472981 106864814 ppf: 419 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Population pharmacokinetics of intravenous valproic acid in Korean patients. aug: au: Park H Kang S Lee Y Shin D Kim O Lee S Yim D affil: Department of Neurology, Ghil Medical Center, Gachon Medical School, Seoul, Korea sug: subj: Epilepsy Drug Therapy Valproic Acid Pharmacokinetics Valproic Acid Therapeutic Use Administration, Intravenous Adolescence Aged, 80 and Over Body Weight Female South Korea Male Middle Age Pearson's Correlation Coefficient Population Prospective Studies Valproic Acid Administration and Dosage Human Adolescent: 13-18 years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: OBJECTIVE: To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults. METHODS: Valproic acid concentrations were obtained using a peak and trough sampling scheme for 102 Korean epileptic patients who were not taking concurrent antiepileptic medication. Three hundred and fifty-four serum concentrations were analysed according to a one-compartment model with a mixed effect modelling method (NONMEM Ver 5.0). The influence of body-weight (kg), height, daily valproic acid dose (mg/day), body mass index (kg/m2), sex, and age on volume of distribution (Vd) and clearance (CL) was assessed in the course of analysis. RESULTS: Vd and CL of valproic acid increased with body-weight. No significant influence of the other screened covariates was observed. The final regression model was: [equation: see text]. Interindividual variabilities (coefficient of variation) for CL and Vd were 32 and 18%, respectively. Residual error including intraindividual variability was 26.7%. CONCLUSION: The current results may be used as a basic reference to optimize drug therapy with intravenous valproic acid. Further research on the paediatric population is necessary to confirm the non-linearity of the relation between body-weight and Vd. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|