Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study.
Background: Folic acid supplements are recommended for women of childbearing age to prevent neural tube defects in their offspring. Results of some studies, however, suggest an increase in multiple births associated with use of vitamin supplements that contain folic acid during pregnancy. Our aim wa...
| Publicado en: | Lancet Vol. 361; no. 9355; pp. 380 - 385 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lancet
2/1/2003
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106866647&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106866647 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 2/1/2003 vid: 361 iid: 9355 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 106866647 106866647 NLM12573374 2003123377 NLM12573374 106866647 ppf: 380 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study. aug: au: Li Z Gindler J Wang H Berry RJ Li S Correa A Zheng J Erickson JD Wang Y Li, Zhu Gindler, Jacqueline Wang, Hong Berry, R J Li, Song Correa, Adolfo Zheng, Jun-chi Erickson, J David Wang, Yu affil: The National Centre for Maternal and Infant Health, and the Department of Health Care Epidemiology, Peking University Health Science Centre, Beijing, China sug: subj: Folic Acid Administration and Dosage Multiple Birth Offspring Pregnancy, Multiple Adult China Confidence Intervals Descriptive Statistics Dietary Supplementation Educational Status Female Logistic Regression Mantel-Haenszel Test Maternal Age Neural Tube Defects Prevention and Control Parity Pregnancy Prospective Studies Funding Source Human Adult: 19-44 years Female ab: Background: Folic acid supplements are recommended for women of childbearing age to prevent neural tube defects in their offspring. Results of some studies, however, suggest an increase in multiple births associated with use of vitamin supplements that contain folic acid during pregnancy. Our aim was to assess this association.Methods: We used data from a population-based cohort study from which we assessed the occurrence of multiple births in women (n=242015) who had participated in a campaign to prevent neural tube defects with folic acid supplements (400 microg per day) in China. Folic acid use was ascertained before pregnancy outcome was known. We studied the relation between multiple births and any use of folic acid pills before or during early pregnancy; additionally, we investigated mechanisms by which folic acid could potentially affect the occurrence of multiple births by examining pill-taking at three time periods: before ovulation, around the time of fertilisation, and after conception.Findings: 1496 (0.62%) multiple births occurred in a cohort of 242015 women who had registered with the study between October, 1993, and September, 1995, and who had a pregnancy not affected by a birth defect; the rate of multiple births in women who did and did not take folic acid before or during early pregnancy was 0.59% and 0.65%, respectively (rate ratio 0.91; 95% CI 0.82-1.00).Interpretation: Our findings suggest that consumption of folic acid supplements during pregnancy is not associated with an increased occurrence of multiple births. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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