Learning difficulties in children treated for acute lymphoblastic leukaemia (ALL)
Concern about the adverse affects of brain irradiation used in treatment for childhood leukaemia on children's learning have been put forward since the 1960s. Early work based on assessment of IQ suggested considerable problems associated with CNS irradiation of 2400cGy, and that children who were y...
| Publicado en: | Pediatric Rehabilitation Vol. 4; no. 3; pp. 105 - 119 |
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| Autores principales: | , |
| Formato: | review Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul-Sep2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106912005&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106912005 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13638491 BC5 jtl: Pediatric Rehabilitation issn: 13638491 maglogo: Y pubinfo: dt: Jul-Sep2001 vid: 4 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106912005 106912005 2002038738 10.1080/13638490110064806 NLM11831563 106912005 ppf: 105 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Learning difficulties in children treated for acute lymphoblastic leukaemia (ALL) aug: au: Eiser C Tillmann V affil: CRC Child and Family Research Group, Department of Psychology, Western Bank, Sheffield S10 2TO, UK; c.eiser@sheffield.ac.uk sug: subj: Learning Disorders Etiology Leukemia, Lymphocytic Drug Therapy Leukemia, Lymphocytic Radiotherapy Outcomes (Health Care) In Infancy and Childhood Age Factors Child Child, Preschool Infant Intelligence Memory Sex Factors Time Factors Child: 6-12 years Child, Preschool: 2-5 years Infant: 1-23 months ab: Concern about the adverse affects of brain irradiation used in treatment for childhood leukaemia on children's learning have been put forward since the 1960s. Early work based on assessment of IQ suggested considerable problems associated with CNS irradiation of 2400cGy, and that children who were younger on diagnosis (below 5 years) were particularly at risk. Consequently, new protocols were introduced in which the amount of irradiation was reduced, or children were treated by chemotherapy alone. There is some evidence that reduction from 2400 to 1800cGy irradiation is beneficial, especially for younger children, as is treatment by chemotherapy alone. Methodological problems in conducting this work and limitations in relying on IQ tests are discussed. Where there are no indications of differences in survival, there would seem to be implications for reducing as far as possible the use of CNS directed therapy among young children treated for leukaemia. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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