Open-label study of a regimen consisting of 1 week of lansoprazole, clarithromycin, and amoxicillin followed by 3 weeks of lansoprazole in healing peptic ulcer and eradicating Helicobacter pylori.
Objective: The aim of the study was to assess the efficacy of a regimen consisting of 1 week of low-dose triple therapy with lansoprazole, amoxicillin, and clarithromycin followed by lansoprazole alone for an additional 3 weeks in the eradication of Helicobacter pylori and the healing of peptic ulce...
| Publicado en: | Current Therapeutic Research Vol. 61; no. 7; pp. 406 - 414 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
2000 Jul
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106918126&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106918126 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0011393X KIH jtl: Current Therapeutic Research issn: 0011393X maglogo: N pubinfo: dt: 2000 Jul vid: 61 iid: 7 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 106918126 106918126 2002045641 106918126 ppf: 406 ppct: 8 formats: tig: atl: Open-label study of a regimen consisting of 1 week of lansoprazole, clarithromycin, and amoxicillin followed by 3 weeks of lansoprazole in healing peptic ulcer and eradicating Helicobacter pylori. aug: au: Archimandritis A Avgerinos A Nakos A Viazis N Skandalis N Tzivras M affil: Department of Pathophysiology, School of Medicine, National University of Athens, 75, Mikras Asias str, Athens 11527, Greece (aarchim@cc.uoa.gr) sug: subj: Drug Therapy, Combination Helicobacter Infections Drug Therapy Helicobacter Pylori Peptic Ulcer Drug Therapy Adolescence Adult Aged Antibiotics Administration and Dosage Antiprotozoal Agents Administration and Dosage Antiulcer Agents Administration and Dosage Biopsy Clinical Research Confidence Intervals Convenience Sample Data Analysis Software Descriptive Statistics Female Greece Histological Techniques Male Middle Age Prospective Studies Treatment Outcomes Evaluation Funding Source Human Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: The aim of the study was to assess the efficacy of a regimen consisting of 1 week of low-dose triple therapy with lansoprazole, amoxicillin, and clarithromycin followed by lansoprazole alone for an additional 3 weeks in the eradication of Helicobacter pylori and the healing of peptic ulcer.Methods: Patients aged >/=16 years with active peptic ulcer diagnosed by endoscopy and H pylori infection were eligible for this prospective, open-label, 3-center study. A triple-drug regimen was used that consisted of lansoprazole 30 mg once daily, amoxicillin 1 g BID, and clarithromycin 250 mg BID for 7 days. Ulcer healing and H pylori eradication were assessed endoscopically 8 to 9 weeks after the start of treatment. Hpylori was determined to be eradicated if both histologic examination and rapid urease testing (4 biopsy samples, antrum [2] and body [2]) were negative.Results: Fifty-five patients who tested positive for H pylori, 49 with duodenal ulcer (DU) and 6 with gastric ulcer (GU), aged 16 to 78 years, were enrolled in the study. Ten patients were lost to follow-up and 1 withdrew from the study because of side effects; 44 patients were included in the per-protocol analyses. H pylori was eradicated in 34 patients, 62% (95% CI, 0.477-0.746) and 77% (95% CI, 0.662-0.885) in the intent-to-treat and perprotocol analyses, respectively. Ulcers were healed in a total of 38 patients (34 DU, 4 GU), 69% in the intent-to-treat population (95% CI, 0.552-0.809) and 86% in the per-protocol population (95% CI, 0.727-0.948). In patients with DU, the rate of healing was 69% in the intent-to-treat analysis (95% CI, 0.546-0.817) and 89% in the per-protocol analysis (95% CI, 0.752-0.971).Conclusions: One week of therapy with lansoprazole 30 mg once daily, amoxicillin 1 g BID, and clarithromycin 250 mg BID, followed by 3 weeks of treatment with lansoprazole 30 mg once daily, effectively healed peptic ulcer but was only moderately effective in eradicating H pylori. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|