Simple biochemical markers to assess chronic wounds.
We investigated the potential for the biochemical analysis of chronic wound fluid to predict healing using simple and widely available analytes in an out-patient clinic setting. Wound fluid was collected from 12 patients attending a leg ulcer clinic and analyzed for a variety of analytes, including...
| Publicado en: | Wound Repair & Regeneration Vol. 8; no. 4; pp. 264 - 270 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2000
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106992002&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106992002 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Aug2000 vid: 8 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106992002 106992002 2001004370 10.1046/j.1524-475x.2000.00264.x 106992002 ppf: 264 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Simple biochemical markers to assess chronic wounds. aug: au: James TJ Hughes MA Cherry GW Taylor RP affil: Department of Clinical Biochemistry, Oxford Radcliffe Hospital, Oxford, OX3 3DU, United Kingdom sug: subj: Wounds, Chronic Physiopathology Exudates and Transudates Analysis Wound Healing Physiology Female Male Aged Aged, 80 and Over Mann-Whitney U Test Albumins Analysis Proteins Analysis Human Aged: 65+ years Aged, 80 & over Female Male ab: We investigated the potential for the biochemical analysis of chronic wound fluid to predict healing using simple and widely available analytes in an out-patient clinic setting. Wound fluid was collected from 12 patients attending a leg ulcer clinic and analyzed for a variety of analytes, including lactate, total protein, and albumin. Twelve weeks after collection the wound was assessed for healing (defined as complete healing or greater than 50% reduction in wound size). The median total protein (44.3 +/- 8.8 g/l) and albumin (25.0 +/- 2.3 g/l) concentrations in exudate collected from four healing wounds were significantly higher (p < 0.05) than in exudate from eight nonhealing wounds (median total protein 29.7 +/- 7.6 g/l, median albumin 17.0 +/- 4.3 g/l). No significant difference was observed for lactate. A second specimen of wound fluid was collected from four of the patients (three nonhealing and one healing). The protein analysis confirmed the pattern observed for the first collection: nonhealing wounds had total protein and albumin which remained low compared to healing wounds. No wound with an exudate albumin of less than 20 g/l healed. Both total protein and albumin are stable analytes which can be easily measured in any laboratory and may offer a simple biomarker of healing in chronic wounds. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|