Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory.
Objective: To assess longitudinally the relationships between plasma levels of estradiol (E2) and free testosterone (T) and cognitive functioning in elderly men, women who use estrogen, and women who do not use estrogen.Design: At two test times 18 months apart (time 1 and time 2), men (time 1, n =...
| Publicado en: | Menopause (10723714) Vol. 7; no. 3; pp. 168 - 178 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2000 May-Jun
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106999178&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106999178 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10723714 N1O jtl: Menopause (10723714) issn: 10723714 maglogo: N pubinfo: dt: 2000 May-Jun vid: 7 iid: 3 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106999178 106999178 NLM10810962 2001014925 10.1097/00042192-200007030-00007 NLM10810962 106999178 ppf: 168 ppct: 10 formats: tig: atl: Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory. aug: au: Carlson LE Sherwin BB Carlson, L E Sherwin, B B affil: Department of Psychology, McGill University, Montreal, Canada sug: subj: Estradiol In Old Age Testosterone In Old Age Memory In Old Age Cognition In Old Age Neuropsychological Tests Geriatric Depression Scale Wechsler Memory Scale-Revised Research Subject Recruitment Prospective Studies Aging Radioimmunoassay Descriptive Statistics Repeated Measures Analysis of Covariance T-Tests Postmenopause Pearson's Correlation Coefficient Hormones Analysis Aged Male Female Funding Source Human Aged: 65+ years Male Female ab: Objective: To assess longitudinally the relationships between plasma levels of estradiol (E2) and free testosterone (T) and cognitive functioning in elderly men, women who use estrogen, and women who do not use estrogen.Design: At two test times 18 months apart (time 1 and time 2), men (time 1, n = 31; time 2, n = 23), women who were using estrogen (time 1, n = 14; time 2, n = 10), and women who were not using estrogen (time 1, n = 41; time 2, n = 27), whose average age was 72.1 and 73.4 years at time 1 and time 2, respectively, were administered a battery of neuropsychological tests that measured verbal memory, visual memory, concentration and attention, language fluency, and semantic memory. Plasma levels of E2 and free T were assessed by radioimmunoassay.Results: The men had higher free T levels than both groups of women at both test times. Although women who were using estrogen had higher E2 levels than those of the men and of the women who were not using estrogen, the men's E2 levels were also significantly higher than those of the women who were not using estrogen. Moreover, the women who were using estrogen and the men had higher Forward Digit Span scores compared with the women who were not using estrogen at both test times, and women who were using estrogen had higher Backward Digit Span scores than those who were not using estrogen. Both groups of women performed better than the men on the Category Retrieval Test (verbal fluency). The performance of women who were using estrogen on the Delayed Selective Reminding Test (long-term rote memory) improved over time compared with that of the men and of the women who were not using estrogen.Conclusions: These findings raise the possibility that higher E2 levels in elderly men and in women who use estrogen may protect against some declines in explicit memory with normal aging. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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