CLO vs histology: optimal numbers and site of gastric biopsies to diagnose Helicobacter pylori.
Objective: To determine the optimal numbers and sites of biopsies required for diagnosis of Helicobacter pylori by using the CLOtest and comparing the results with those of a routine histological assessment in a district general hospital (DGH) setting.Methods: A prospective study comparing the sensi...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 13; no. 4; pp. 387 - 391 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2001 Apr
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107038379&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107038379 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2001 Apr vid: 13 iid: 4 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 107038379 107038379 NLM11338067 2001063975 10.1097/00042737-200104000-00014 NLM11338067 107038379 ppf: 387 ppct: 4 formats: tig: atl: CLO vs histology: optimal numbers and site of gastric biopsies to diagnose Helicobacter pylori. aug: au: Vassallo J Hale R Ahluwalia NK Vassallo, J Hale, R Ahluwalia, N K affil: Royal Oldham Hospital, Oldham, UK sug: subj: Helicobacter Infections Diagnosis Diagnosis, Laboratory Methods Biopsy Urease Analysis Sensitivity and Specificity Prospective Studies Data Analysis, Statistical Funding Source Human ab: Objective: To determine the optimal numbers and sites of biopsies required for diagnosis of Helicobacter pylori by using the CLOtest and comparing the results with those of a routine histological assessment in a district general hospital (DGH) setting.Methods: A prospective study comparing the sensitivity of the CLOtest containing one antral (CLO 1), two antral (CLO 2) and two antral and one body biopsy (CLO 3), and with histological examination for H. pylori. Consecutive patients undergoing upper gastrointestinal endoscopy (UGIE) at Stepping Hill Hospital, Stockport, UK, who had evidence of gastritis, gastric ulcer, duodenitis or duodenal ulcer were included in the study.Results: Ninety-six patients were biopsied. Forty were positive on at least one of the CLOtests; of these, nine were negative on histological assessment. Of these nine, two were positive on all CLOtests and seven were positive only on CLO 3. One was positive on histology but negative on all CLOtests. This study showed that CLO 3 was more sensitive than CLO 1 (P = 0.004), CLO 2 (P = 0.016) and histology (P = 0.022). There was no significant difference between CLO 1 and CLO 2 (P = 0.500), CLO 1 and histology (P = 1.000), CLO 2 and histology (P = 1.00).Conclusion: We feel that in a busy clinical setting, taking two antral and one body biopsy in a single CLOtest is superior to routine histological assessment for the detection of H. pylori, with resulting cost saving. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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