Peripheral nerve dysfunction in farmers using organophosphate sheep dip.
Purpose: To investigate the function of the peripheral and central nervous system in farmers regularly using organophosphate (OP) compounds either after acute intoxication or following low level repeated exposure. Design: Case control and cross-sectional studies. Materials and Methods: Two groups, e...
| Publicado en: | Journal of Nutritional & Environmental Medicine Vol. 11; no. 1; pp. 9 - 23 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107043824&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107043824 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13590847 JNU jtl: Journal of Nutritional & Environmental Medicine issn: 13590847 maglogo: Y pubinfo: dt: Mar2001 vid: 11 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 107043824 2001072750 10.1080/13590840020030221 107043824 ppf: 9 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Peripheral nerve dysfunction in farmers using organophosphate sheep dip. aug: au: Jamal GA Hansen S Ecne FA Ecne AP Abdul-Aziz M Ballantyne JP affil: Department of Neurology, Institute of Neurological Sciences, South Glasgow University Hospitals NHS Trust, Glasgow, UK sug: subj: Peripheral Nervous System Physiology Central Nervous System Physiology Farmworkers Insecticides Poisoning Case Control Studies Cross Sectional Studies Sheep Comparative Studies Functional Assessment Neural Conduction Evaluation Electromyography Vision Tests Evoked Potentials, Somatosensory Neurophysiology Male Female Adult Descriptive Statistics Middle Age Aged Poisoning Symptoms Sensation Evaluation Analysis of Variance Kruskal-Wallis Test Confidence Intervals T-Tests Two-Tailed Test Mann-Whitney U Test Data Analysis Software Erythrocytes Analysis Acetylcholinesterase Blood Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: To investigate the function of the peripheral and central nervous system in farmers regularly using organophosphate (OP) compounds either after acute intoxication or following low level repeated exposure. Design: Case control and cross-sectional studies. Materials and Methods: Two groups, each of sixteen farmers regularly involved in dipping sheep, were compared with a group of sixteen healthy controls of similar age range using clinical neurological and neurophysiological assessment. Farmers in group 1 had long-term ill health following episodes of mild to moderate acute OP poisoning while farmers in group 2 had none of the above. Clinical symptoms and signs of neuropathy were recorded. Motor and sensory nerve conduction, electromyography (EMG), quantitative sensory testing and visual, brainstem auditory and somatosensory evoked potentials were measured. Results: A similar pattern of significant abnormalities of distal sensory and motor peripheral nerve axonal dysfunction was found in both farmer groups, but more pronounced in the symptomatic farmers. Conclusions: The findings suggest that long-term peripheral neuropathy can follow acute OP intoxication (group 1). Furthermore, chronic effects may follow repetitive low level exposure to OP compounds (group 2). The profile of dysfunction was similar in the two groups. The parameters measured in the study are useful endpoints in future epidemiological studies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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