The pineal aging and death program. I. Grafting of old pineals in young mice accelerates their aging.
Experimental work initiated in 1985 progressively demonstrated the aging-delaying and/or life-prolonging effects of circadian, nocturnal administration of the pineal indoleamine melatonin in old rodents, and the even more pronounced aging-delaying effects of young-to-old pineal grafting. Another mod...
| Publicado en: | Journal of Anti-Aging Medicine Vol. 4; no. 1; pp. 31 - 38 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
2001 Spring
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107047244&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107047244 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10945458 C1H jtl: Journal of Anti-Aging Medicine issn: 10945458 maglogo: N pubinfo: dt: 2001 Spring vid: 4 iid: 1 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 107047244 107047244 2001076199 107047244 ppf: 31 ppct: 7 formats: tig: atl: The pineal aging and death program. I. Grafting of old pineals in young mice accelerates their aging. aug: au: Pierpaoli W Bulian D affil: Jean Choay Institute for Biomedical Research, Via Industria 16, 6826 Riva San Vitale, Switzerland. E-mail: chrono@dial.eunet.ch sug: subj: Pineal Gland Physiology Aging Physiology Animal Studies Mice Pineal Gland Transplantation Blood Specimen Collection Descriptive Statistics Analysis of Variance Paired T-Tests Log-Rank Test Age Factors ab: Experimental work initiated in 1985 progressively demonstrated the aging-delaying and/or life-prolonging effects of circadian, nocturnal administration of the pineal indoleamine melatonin in old rodents, and the even more pronounced aging-delaying effects of young-to-old pineal grafting. Another model, in which young pinealectomized mice were transplanted with pineal glands from older donors, showed a remarkable aging-accelerating effect produced in the younger mice by the 'old' pineal. More work showed that, not only the course of aging can be modified, but even reversed. Apparently, aging is an evolutionary and developmental program similar to growth, onset of puberty and maintenance of fertility, and is amenable to be modified. The novel observation is reported here that implantation of pineal glands from very old donors into the thymus of normal, non-pinealectomized young hosts, accelerates their aging and induces an earlier death. No effect on aging and longevity can be seen when the young mice are transplanted with a pineal gland from young donors. It thus seems that the grafted pineal gland from a very old donor delivers active 'aging and death messages' that cannot be permanently antagonized by the existing own 'young' pineal gland in the host. This new observation also suggests that the 'program of aging,' even in a disease-free individual, may be different from the 'program of death.' In fact, a very old pineal gland seems to dominate on a young pineal and thus produce an earlier death at a time when the genetically determined neuroendocrine program of growth, fertility and aging in the engrafted old pineal has expired. The mechanism for the explication of these aging-promoting mechanisms in the 'pineal network' is under investigation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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