Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial.
Objective: To compare dual therapy (omeprazole and amoxicillin) with triple therapy (omeprazole, amoxicillin, and clarithromycin) in the treatment of Helicobacter pylori infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared with 2 mg/kg/day.Study Design: 252 patients (median age, 1...
| Publicado en: | Archives of Disease in Childhood Vol. 81; no. 1; pp. 68 - 71 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
BMJ Publishing Group
Jul1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107058922&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107058922 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039888 6PU jtl: Archives of Disease in Childhood issn: 00039888 maglogo: N pubinfo: dt: Jul1999 vid: 81 iid: 1 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 107058922 107058922 NLM10373140 2001093824 10.1136/adc.81.1.68 NLM10373140 107058922 ppf: 68 ppct: 3 formats: tig: atl: Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial. aug: au: Behrens R Lang T Keller KM Bindl L Becker M Rodeck B Küster P Wündisch GF Stolte M Behrens, R Lang, T Keller, K M Bindl, L Becker, M Rodeck, B Küster, P Wündisch, G F Stolte, M affil: Department Pediatric Gastroenterology, University of Erlangen, Loschgestr. 15, D-91054 Erlangen, Germany sug: subj: Helicobacter Infections Drug Therapy Antibiotics, Combined Therapeutic Use Drug Combinations Breath Tests Treatment Outcomes Omeprazole Administration and Dosage Amoxicillin Administration and Dosage Clarithromycin Administration and Dosage Clinical Trials Chi Square Test Child, Preschool Child Adolescence Female Male Human Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Female Male ab: Objective: To compare dual therapy (omeprazole and amoxicillin) with triple therapy (omeprazole, amoxicillin, and clarithromycin) in the treatment of Helicobacter pylori infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared with 2 mg/kg/day.Study Design: 252 patients (median age, 11.0 years; range, 3-18) presenting with chronic abdominal pain underwent endoscopy and a 13C-urea breath test. Gastric biopsy specimens were taken for histological examination and for the rapid urease test. Patients were treated for two weeks: group A (n = 63) received amoxicillin (50 mg/kg; maximum, 2 g/day), group B (n = 73) received amoxicillin and clarithromycin (20 mg/kg; maximum, 1 g/day). Both groups were randomly treated with either 1 or 2 mg/kg omeprazole (maximum, 80 mg/day). Diagnostic procedures were repeated four weeks after the end of treatment.Results: 11 patients were excluded; 136 patients were H pylori positive (56%), 105 of whom were re-examined after treatment. Helicobacter pylori was eradicated in 52% of group A and 83% of group B. The dose of omeprazole had no influence on the eradication rate. Specificity and sensitivity of the rapid urease test were 94% and 93%, respectively. Specificity and sensitivity of the 13C-urea breath test were 93% and 95%, respectively.Conclusions: Dual therapy can no longer be recommended. Triple therapy is more effective than dual therapy in the eradication of H pylori infection. The lower dose of 1 mg/kg omeprazole was as effective as 2 mg/kg. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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