Folic acid supplements during pregnancy and risk of miscarriage.
Background: Although taking supplements that contain 400 microg of folic acid before and during early pregnancy reduces a woman's risk for having a baby with a neural-tube defect (NTD), the effects of such supplements on other pregnancy outcomes remain unclear. We examined whether the use of such su...
| Publicado en: | Lancet Vol. 358; no. 9284; pp. 796 - 801 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lancet
9/8/2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107068478&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107068478 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 9/8/2001 vid: 358 iid: 9284 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 107068478 107068478 NLM11564486 2001104923 10.1016/s0140-6736(01)05969-4 NLM11564486 107068478 ppf: 796 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Folic acid supplements during pregnancy and risk of miscarriage. aug: au: Gindler J Li Z Berry RJ Zheng J Correa A Sun X Wong L Cheng L Erickson JD Wang Y Tong Q Gindler, J Li, Z Berry, R J Zheng, J Correa, A Sun, X Wong, L Cheng, L Erickson, J D affil: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA sug: subj: Folic Acid Administration and Dosage Folic Acid Adverse Effects Abortion, Spontaneous Chemically Induced Pregnancy Abortion, Spontaneous Epidemiology China T-Tests Confidence Intervals Adult Female Funding Source Human Adult: 19-44 years Female ab: Background: Although taking supplements that contain 400 microg of folic acid before and during early pregnancy reduces a woman's risk for having a baby with a neural-tube defect (NTD), the effects of such supplements on other pregnancy outcomes remain unclear. We examined whether the use of such supplements affects the occurrence of miscarriage.Methods: Participants were women in China who had taken part in a recent folic acid campaign to prevent NTDs and who had registered in this campaign before they became pregnant for the first time. We examined the risk for miscarriage among women who had confirmed pregnancies and who had or had not taken pills containing only 400 microg of folic acid before and during early pregnancy.Results: The overall rate of miscarriage was 9.1% (2155/23806). The rates of miscarriage among women who had and had not taken folic acid pills before and during the first trimester were 9.0% and 9.3%, respectively (risk ratio 0.97 [95% CI 0.84-1.12]). The distributions of gestational age at pregnancy diagnosis and at miscarriage were similar for both groups of women.Interpretation: In this population-based study of a cohort of women whose use of folic acid supplements while pregnant had been previously documented and who had been pregnant for the first time, we found no evidence that daily consumption of 400 microg of folic acid before and during early pregnancy influenced their risk for miscarriage. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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