Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation.
Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-I) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that trans...
| Publicado en: | Nutrition & Cancer Vol. 36; no. 2; pp. 150 - 155 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
2000
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107075597&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107075597 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2000 vid: 36 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 107075597 107075597 2001112893 10.1207/s15327914nc3602_2 NLM10890024 107075597 ppf: 150 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. aug: au: Cascante M Centelles JJ Veech RL Lee WP Boros LG affil: Department of Biochemistry and Molecular Biology, Institut d'Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia 08028, Spain sug: subj: Thiamine Neoplasms Physiopathology Neoplastic Processes Transferases Metabolism Transferases Antagonists and Inhibitors Cell Physiology Neoplasms Drug Therapy Nucleic Acids ab: Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-I) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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