Neurocognitive deficits in medulloblastoma survivors and white matter loss.
Although previous studies have documented a significant risk of intellectual loss after treatment for childhood medulloblastoma (MED), the pathophysiology underlying this process is poorly understood. The purpose of this study was to test the hypotheses that (1) patients treated for MED in childhood...
| Publicado en: | Annals of Neurology Vol. 46; no. 6; pp. 834 - 842 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107087887&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107087887 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03645134 1WM jtl: Annals of Neurology issn: 03645134 maglogo: Y pubinfo: dt: 1999 vid: 46 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 107087887 107087887 NLM10589535 2000007594 NLM10589535 107087887 ppf: 834 ppct: 8 formats: tig: atl: Neurocognitive deficits in medulloblastoma survivors and white matter loss. aug: au: Mulhern RK Reddick WE Palmer SL Glass JO Elkin TD Kun LE Taylor J Langston J Gajjar A Mulhern, R K Reddick, W E Palmer, S L Glass, J O Elkin, T D Kun, L E Taylor, J Langston, J Gajjar, A affil: Department of Diagnostic Imaging, St Jude Children's Research Hopital, Memphis, TN 38105-2794, USA sug: subj: Cancer Survivors Brain Neoplasms Therapy Cognition Disorders Etiology Child Neuropsychological Tests Intelligence Tests Radiotherapy Adverse Effects Magnetic Resonance Imaging Brain Neoplasms Radiotherapy Brain Neoplasms Drug Therapy Antineoplastic Agents, Combined Adverse Effects Wechsler Adult Intelligence Scale-Revised Age of Onset Comparative Studies Regression Female Male Funding Source Human Child: 6-12 years Female Male ab: Although previous studies have documented a significant risk of intellectual loss after treatment for childhood medulloblastoma (MED), the pathophysiology underlying this process is poorly understood. The purpose of this study was to test the hypotheses that (1) patients treated for MED in childhood have reduced volumes of normal white matter (NWM) related to their treatment with craniospinal irradiation with or without chemotherapy, and (2) deficits in NWM among patients surviving MED can at least partially explain deficits in their intellectual performance. Eighteen pediatric patients previously treated for MED were matched on the basis of age at the time of evaluation to 18 patients previously treated for low-grade posterior fossa tumors with surgery alone (mean difference, 3.7 months). Evaluations were conducted with age-appropriate neurocognitive testing and quantitative magnetic resonance imaging by using a novel automated segmentation and classification algorithm constructed from a hybrid neural network. Patients treated for MED had significantly less NWM (p < 0.01) and significantly lower Full-Scale IQ values than those treated for low-grade tumors (mean, 82.1 vs 92.9). In addition, NWM had a positive and statistically significant association with Full-Scale IQ among the patients treated for MED. We conclude that irradiation- or chemotherapy-induced destruction of NWM can at least partially explain intellectual and academic achievement deficits among MED survivors. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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