Circumscribed cognitive dysfunction in middle-aged adults with type 2 diabetes.
Objective: To examine the extent to which type 2 diabetes is associated with poorer performance on measures of learning, memory, psychomotor speed, and problem-solving in middle-aged adults.Research Design and Methods: This cross-sectional study evaluated 50 adults (age range 34-65 years, mean 50.8)...
| Publicado en: | Diabetes Care Vol. 23; no. 10; pp. 1486 - 1494 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
American Diabetes Association
Oct2000
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107152877&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107152877 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01495992 1G7 jtl: Diabetes Care issn: 01495992 maglogo: N pubinfo: dt: Oct2000 vid: 23 iid: 10 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 107152877 107152877 NLM11023141 2000075523 10.2337/diacare.23.10.1486 NLM11023141 107152877 ppf: 1486 ppct: 8 formats: tig: atl: Circumscribed cognitive dysfunction in middle-aged adults with type 2 diabetes. aug: au: Ryan CM Geckle MO Ryan, C M Geckle, M O affil: Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA sug: subj: Diabetes Mellitus, Type 2 Complications Cognition Disorders Epidemiology Cross Sectional Studies Neuropsychological Tests Intelligence Tests Multiple Regression Wechsler Adult Intelligence Scale-Revised Wechsler Memory Scale-Revised Symptom Checklist-90-Revised Regression Two-Tailed Test T-Tests Chi Square Test Descriptive Statistics Data Analysis, Statistical Data Analysis Software Confidence Intervals P-Value Factor Analysis Memory Problem Solving Spearman's Rank Correlation Coefficient Middle Age Male Female Funding Source Human Middle Aged: 45-64 years Male Female ab: Objective: To examine the extent to which type 2 diabetes is associated with poorer performance on measures of learning, memory, psychomotor speed, and problem-solving in middle-aged adults.Research Design and Methods: This cross-sectional study evaluated 50 adults (age range 34-65 years, mean 50.8) with type 2 diabetes and 50 demographically similar community control subjects without diabetes. Each subject received a thorough physical examination and a detailed neuropsychological assessment. Factor analysis was used to assign specific tests to 1 of 4 cognitive domains (learning, memory for stories, problem-solving, and psychomotor speed). Hierarchical regression analysis was used to identify demographic and biomedical variables associated with cognitive dysfunction.Results: Learning, memory, and problem-solving skills were unaffected by type 2 diabetes. In contrast, psychomotor slowing was predicted by a diagnosis of diabetes (r2 change = 0.075, P < 0.002) with additional variance in psychomotor efficiency explained independently by HbA1 (r2 = 0.064, P < 0.003) and vibratory threshold (r2 = 0.112, P < 0.0001). The magnitude of psychomotor slowing on specific tests ranged from 12% (Digit Vigilance) to 23% (Grooved Pegboard).Conclusions: Middle-aged adults with type 2 diabetes manifest psychomotor slowing that is associated with poorer metabolic control, whereas learning, memory, and problem-solving skills appear to be largely intact. The development of psychomotor slowing may be a manifestation of a "central neuropathy" induced by chronic hyperglycemia. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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