Multicentre randomised study of computerised anticoagulant dosage. European Concerted Action on Anticoagulation.
Background: The demand for anticoagulant treatment is increasing. We compared the benefits of computer-generated anticoagulant dosing with traditional dosing decided by experienced medical staff in achieving target international normalised ratios (INRs).Methods: In five European centres we randomly...
| Publicado en: | Lancet Vol. 352; no. 9139; pp. 1505 - 1510 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Lancet
11/7/1998
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107159054&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107159054 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 11/7/1998 vid: 352 iid: 9139 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 107159054 107159054 NLM9820298 1999003944 10.1016/s0140-6736(98)04147-6 NLM9820298 107159054 ppf: 1505 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Multicentre randomised study of computerised anticoagulant dosage. European Concerted Action on Anticoagulation. aug: au: Poller L Shiach CR MacCallum PK Johansen AM Munster AM Magalhaes A Jespersen J Poller, L Shiach, C R MacCallum, P K Johansen, A M Münster, A M Magalhães, A Jespersen, J affil: Department of Pathological Sciences, University of Manchester, UK sug: subj: Anticoagulants Administration and Dosage Drug Therapy, Computer Assisted Blood Coagulation Software Dosage Calculation Administration, Oral Blood Coagulation Tests Anticoagulants Therapeutic Use Clinical Trials Data Analysis, Statistical Human ab: Background: The demand for anticoagulant treatment is increasing. We compared the benefits of computer-generated anticoagulant dosing with traditional dosing decided by experienced medical staff in achieving target international normalised ratios (INRs).Methods: In five European centres we randomly assigned 285 patients in the stabilisation period and stabilised patients to the computer-generated-dose group (n=137) or traditional-dose group (n=148). Centres had a specialist interest in oral anticoagulation but no previous experience with computer-generated dosing. The computer program calculated doses and times to next visit. Our main endpoint was time spent in target INR range (Rosendaal method).Findings: For all patients combined, computer-generated dosing was significantly beneficial overall in achieving target INR (p=0.004). The mean time within target INR range for all patients and all ranges was 63.3% (SD 28.0) of days in the computer-generated-dose group compared with 53.2% (27.7) in the traditional-dose group. For the stabilisation patients alone, computer-generated doses led to a non-significant benefit in all INR ranges (p=0.06), whereas in the stable patients the benefit was significant (p=0.02).Interpretation: The computer program gave better INR control than the experienced medical staff and at least similar standards to the specialised centres should be generally available. Clinical outcome and cost effectiveness remain to be assessed. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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