Surveillance of cryptococcosis in Alabama, 1992-1994.
Purpose: Although cryptococcosis is a significant opportunistic infection among patients with human immunodeficiency virus (HIV), there is conflicting information on rates of cryptococcosis among HIV-positive and HIV-negative patients. Precise state-wide epidemiologic data for cryptococcosis are not...
| Publicado en: | Annals of Epidemiology Vol. 8; no. 4; pp. 212 - 217 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
1998 May
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107169454&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107169454 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10472797 J8R jtl: Annals of Epidemiology issn: 10472797 maglogo: N pubinfo: dt: 1998 May vid: 8 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 107169454 107169454 NLM9590599 1999015762 10.1016/s1047-2797(97)00234-2 NLM9590599 107169454 ppf: 212 ppct: 5 formats: tig: atl: Surveillance of cryptococcosis in Alabama, 1992-1994. aug: au: Thomas CJ Lee JY Conn LA Bradley ME Gillespie RW Dill SR Pinner RW Pappas PG Thomas, C J Lee, J Y Conn, L A Bradley, M E Gillespie, R W Dill, S R Pinner, R W Pappas, P G affil: University of Alabama at Birmingham, USA sug: subj: Cryptococcosis Epidemiology AIDS-Related Opportunistic Infections Epidemiology Epidemiological Research Alabama Cryptococcus Step-Wise Multiple Regression P-Value Adult Middle Age Aged Male Female Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Although cryptococcosis is a significant opportunistic infection among patients with human immunodeficiency virus (HIV), there is conflicting information on rates of cryptococcosis among HIV-positive and HIV-negative patients. Precise state-wide epidemiologic data for cryptococcosis are not available in Alabama.Methods: We conducted an active laboratory and hospital medical record-based surveillance for cryptococcosis in Alabama from October 1, 1992 to September 30, 1994. A case of cryptococcosis was defined as a patient's initial episode of cryptococcal disease and based on either a positive culture for C. neoformans from any normally sterile site, a positive latex agglutination serologic test for cryptococcal antigen in CSF or serum, or histopathologic findings consistent with C. neoformans.Results: Over the two year period, 153 cases were identified. The diagnosis was based on positive culture (37%), positive antigen (24%), positive autopsy culture (2%), and histopathologic findings (4%). Further, 33% of the total cases were diagnosed from combined positive culture, antigen, or histopathology. Of the total 153 cases, 55% were in HIV-positive patients and 44% were in HIV-negative individuals and one case (1%) had an unknown HIV status. The overall annual incidence rate of cryptococcosis was 1.89 cases per 100,000 population. The incidence was 1638.7 per 100,000 in the HIV-positive population and 0.84 per 100,000 in the HIV-negative population.Conclusion: The first Alabama statewide active surveillance system for cryptococcosis confirms previous observations that rates of cryptococcosis are consistently higher in HIV-infected individuals than in their HIV-negative counterparts. In Alabama, cryptococcosis occurs more commonly in urban residents and in men. Cryptococcosis in HIV-positive persons is more likely to occur in the 20 to 44 year age group, whereas cryptococcosis in HIV-negative persons is more likely to occur in those greater than 45 years old. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|